244275

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 183906..184411 Replicon chromosome
Accession NZ_CP096960
Organism Pseudomonas aeruginosa strain NY11254

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag M2I99_RS00805 Protein ID WP_003083773.1
Coordinates 183906..184187 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag M2I99_RS00810 Protein ID WP_003083775.1
Coordinates 184184..184411 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2I99_RS00780 (M2I99_00780) 179157..180506 + 1350 WP_003137006.1 C4-dicarboxylate transporter DctA -
M2I99_RS00785 (M2I99_00785) 180555..181241 + 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
M2I99_RS00790 (M2I99_00790) 181342..182076 + 735 WP_003083764.1 GntR family transcriptional regulator -
M2I99_RS00795 (M2I99_00795) 182256..182666 + 411 WP_003110659.1 aegerolysin family protein -
M2I99_RS00800 (M2I99_00800) 182698..183606 - 909 WP_003083769.1 LysR family transcriptional regulator -
M2I99_RS00805 (M2I99_00805) 183906..184187 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
M2I99_RS00810 (M2I99_00810) 184184..184411 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
M2I99_RS00815 (M2I99_00815) 184587..185207 - 621 WP_003101226.1 hypothetical protein -
M2I99_RS00820 (M2I99_00820) 185308..185808 + 501 WP_003083778.1 LEA type 2 family protein -
M2I99_RS00825 (M2I99_00825) 185881..186222 + 342 WP_014603467.1 zinc ribbon domain-containing protein YjdM -
M2I99_RS00830 (M2I99_00830) 186304..187731 - 1428 WP_003083784.1 GABA permease -
M2I99_RS00835 (M2I99_00835) 187900..189393 - 1494 WP_003083788.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T244275 WP_003083773.1 NZ_CP096960:c184187-183906 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT244275 WP_003083775.1 NZ_CP096960:c184411-184184 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References