Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1098349..1098941 Replicon chromosome
Accession NC_013508
Organism Edwardsiella tarda EIB202

Toxin (Protein)


Gene name Hha Uniprot ID D0ZEC2
Locus tag ETAE_RS04770 Protein ID WP_012847872.1
Coordinates 1098349..1098552 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID D0ZEC3
Locus tag ETAE_RS04775 Protein ID WP_012847873.1
Coordinates 1098573..1098941 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ETAE_RS04745 (ETAE_1001) 1094026..1094487 + 462 WP_012847865.1 Lrp/AsnC family transcriptional regulator -
ETAE_RS04750 (ETAE_1003) 1094792..1095130 + 339 WP_012847867.1 P-II family nitrogen regulator -
ETAE_RS04755 (ETAE_1004) 1095152..1096432 + 1281 WP_041692495.1 ammonium transporter AmtB -
ETAE_RS04760 (ETAE_1005) 1096467..1097333 - 867 WP_012847869.1 acyl-CoA thioesterase II -
ETAE_RS04765 (ETAE_1006) 1097442..1097798 - 357 WP_012847870.1 MGMT family protein -
ETAE_RS04770 (ETAE_1008) 1098349..1098552 - 204 WP_012847872.1 hemolysin expression modulator Hha Toxin
ETAE_RS04775 (ETAE_1009) 1098573..1098941 - 369 WP_012847873.1 Hha toxicity modulator TomB Antitoxin
ETAE_RS04780 (ETAE_1010) 1099309..1102461 - 3153 WP_012847874.1 multidrug efflux RND transporter permease subunit -
ETAE_RS04785 (ETAE_1011) 1102505..1103689 - 1185 WP_012847875.1 efflux RND transporter periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-115)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8103.37 Da        Isoelectric Point: 5.0914

>T24427 WP_012847872.1 NC_013508:c1098552-1098349 [Edwardsiella tarda EIB202]
MTKIDYLMKLRKCTTLDTLERVIEKNKYELSDDELEIFYSAADHRLAELTMNKLYDKIPAEVWQYVR

Download         Length: 204 bp

>T24427 NC_013508:c1098552-1098349 [Edwardsiella tarda EIB202]
ATGACCAAGATCGATTATCTGATGAAGCTGCGTAAATGCACGACGCTGGATACTCTAGAACGCGTGATCGAAAAGAATAA
ATACGAACTTTCAGATGATGAATTAGAAATTTTTTATTCTGCCGCAGATCATCGTCTGGCCGAATTAACTATGAATAAGC
TATACGACAAAATTCCAGCAGAAGTCTGGCAATACGTCCGCTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14129.83 Da        Isoelectric Point: 6.1484

>AT24427 WP_012847873.1 NC_013508:c1098941-1098573 [Edwardsiella tarda EIB202]
MDEYTSYQHDIAELKYLCDSLYHQGIDVLGESHHGWVSDPTAKVNLQLNELIEHIASVAQSFKIKYPHHSDLAEILDDYL
DETYALFGAYSVSETALRHWLRTKRRVAYCLAHEKRNATLHV

Download         Length: 369 bp

>AT24427 NC_013508:c1098941-1098573 [Edwardsiella tarda EIB202]
ATGGATGAGTACACTTCTTATCAGCATGACATCGCAGAGTTAAAATACCTGTGTGATTCTCTGTATCATCAGGGAATAGA
TGTCCTGGGAGAGAGCCATCACGGCTGGGTCAGCGACCCGACGGCAAAGGTAAATCTACAGCTTAATGAGCTGATTGAGC
ATATTGCCAGCGTCGCGCAATCATTTAAGATCAAATATCCGCATCATTCGGATTTAGCCGAAATATTGGATGATTATCTG
GATGAAACCTATGCCCTGTTTGGCGCCTATAGCGTCAGTGAAACGGCGCTCCGGCACTGGCTGCGCACCAAGCGGCGGGT
GGCATACTGCCTGGCGCATGAAAAGCGCAACGCTACCTTACATGTTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A034SMG4

Antitoxin

Source ID Structure
AlphaFold DB D0ZEC3

References