Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) slvAT/RES(toxin)
Location 154016..154932 Replicon plasmid pNY11173-DIM
Accession NZ_CP096957
Organism Pseudomonas aeruginosa strain NY11173

Toxin (Protein)


Gene name slvT Uniprot ID -
Locus tag M2I96_RS31430 Protein ID WP_172688507.1
Coordinates 154016..154540 (-) Length 175 a.a.

Antitoxin (Protein)


Gene name slvA Uniprot ID A0A2L1KH13
Locus tag M2I96_RS31435 Protein ID WP_019437782.1
Coordinates 154537..154932 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2I96_RS31410 (M2I96_31325) 149319..150404 + 1086 WP_172688502.1 sugar diacid recognition domain-containing protein -
M2I96_RS31415 (M2I96_31330) 150529..151674 + 1146 WP_172688503.1 glycerate kinase -
M2I96_RS31420 (M2I96_31335) 152121..152312 - 192 WP_172688505.1 hypothetical protein -
M2I96_RS31425 (M2I96_31340) 152720..153970 + 1251 WP_172688506.1 TerD family protein -
M2I96_RS31430 (M2I96_31345) 154016..154540 - 525 WP_172688507.1 RES family NAD+ phosphorylase Toxin
M2I96_RS31435 (M2I96_31350) 154537..154932 - 396 WP_019437782.1 hypothetical protein Antitoxin
M2I96_RS31440 (M2I96_31355) 155514..157397 - 1884 WP_235375613.1 helicase -
M2I96_RS31445 (M2I96_31360) 158383..158868 + 486 WP_172688509.1 hypothetical protein -
M2I96_RS31450 (M2I96_31365) 159486..159890 + 405 WP_010794448.1 response regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid ant(3'')-Ia / blaOXA-4 / catB3 / dfrB3 / blaDIM-1 / aph(6)-Id / aph(3'')-Ib / aac(6')-IIa / qacE / floR / sul1 / dfrA1 / qnrVC6 - 1..412305 412305


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(10-166)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 175 a.a.        Molecular weight: 19070.64 Da        Isoelectric Point: 4.7039

>T244266 WP_172688507.1 NZ_CP096957:c154540-154016 [Pseudomonas aeruginosa]
MKIIGVQDLPCYRMHTPKWSVAPTSGAGAATQGGRVNRKGLEALYLSLESATAIAEFQQASAFLPPGLLVSYSLSMDRVI
DFTGGYNDTWAPIWQDFFCDWRKIRFNDGVEPPSWIIGDLAIEADCAGILFESVANPGGRNLVLFTDQLPVHGKLVVNDP
RGDLPTDQSSWTRP

Download         Length: 525 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14753.87 Da        Isoelectric Point: 7.2048

>AT244266 WP_019437782.1 NZ_CP096957:c154932-154537 [Pseudomonas aeruginosa]
MASKAVLELRPTNFAGLMDALKEVNRVMFSPERFLKVFSMDQQTLALRAHVHRNTVRNAPESEKVQAYIRDSVKVLRAVT
DMGTDVTNAIFWFKNEPLSTFGYKTAEEVVSEGKTEQLIAFLQSWEAGAQG

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2L1KH13

References