Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 4603258..4604516 Replicon chromosome
Accession NZ_CP096956
Organism Pseudomonas aeruginosa strain NY11173

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag M2I96_RS21420 Protein ID WP_019725936.1
Coordinates 4603258..4604013 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag M2I96_RS21425 Protein ID WP_003086329.1
Coordinates 4604148..4604516 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2I96_RS21410 (M2I96_21340) 4598430..4600973 + 2544 WP_003112526.1 acyl-homoserine-lactone acylase QuiP -
M2I96_RS21415 (M2I96_21345) 4601128..4602489 - 1362 WP_003081943.1 DNA recombination protein RmuC -
M2I96_RS21420 (M2I96_21350) 4603258..4604013 - 756 WP_019725936.1 RES family NAD+ phosphorylase Toxin
M2I96_RS21425 (M2I96_21355) 4604148..4604516 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
M2I96_RS21430 (M2I96_21360) 4604589..4605875 - 1287 WP_003163134.1 FAD-binding oxidoreductase -
M2I96_RS21435 (M2I96_21365) 4605931..4607424 - 1494 WP_003086325.1 aldehyde dehydrogenase family protein -
M2I96_RS21440 (M2I96_21370) 4607599..4608075 + 477 WP_019725934.1 hypothetical protein -
M2I96_RS21445 (M2I96_21375) 4608078..4608353 - 276 WP_010792073.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28192.33 Da        Isoelectric Point: 8.0554

>T244262 WP_019725936.1 NZ_CP096956:c4604013-4603258 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSGHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT244262 WP_003086329.1 NZ_CP096956:c4604516-4604148 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References