Detailed information of TA system TA244260

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Acetyltransf_4(toxin)
• Location: 1869205..1870713
• Replicon: chromosome
• Accession: NZ_CP096956
• Organism: Pseudomonas aeruginosa strain NY11173

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: M2I96_RS08765
• Protein ID: WP_012613851.1
• Coordinates: 1869205..1869792 (+)
• Length: 196 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: M2I96_RS08770
• Protein ID: WP_019726549.1
• Coordinates: 1869859..1870713 (+)
• Length: 285 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M2I96_RS08760 (M2I96_08740)	1865460..1868939	-	3480	WP_003117605.1	PAS domain-containing hybrid sensor histidine kinase/response regulator	-
M2I96_RS08765 (M2I96_08745)	1869205..1869792	+	588	WP_012613851.1	GNAT family protein	Toxin
M2I96_RS08770 (M2I96_08750)	1869859..1870713	+	855	WP_019726549.1	AraC family transcriptional regulator	Antitoxin
M2I96_RS08775 (M2I96_08755)	1870810..1872975	+	2166	WP_003091606.1	TonB-dependent receptor family protein	-
M2I96_RS08780 (M2I96_08760)	1873150..1875024	+	1875	WP_019726548.1	MFS transporter	-
M2I96_RS08785 (M2I96_08765)	1875084..1875293	-	210	WP_003115568.1	cold-shock protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (20-152)

Antitoxin

• AraC-type arabinose-binding/dimerisation domain (19-151)

Sequences

Toxin

Protein

• Length: 196 a.a.
• Molecular weight: 21929.29 Da
• Isoelectric Point: 9.8676

>T244260 WP_012613851.1 NZ_CP096956:1869205-1869792 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAVLEASFTG

Nucleotide

• Length: 588 bp

Antitoxin

Protein

• Length: 285 a.a.
• Molecular weight: 31880.18 Da
• Isoelectric Point: 7.1639

>AT244260 WP_019726549.1 NZ_CP096956:1869859-1870713 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFCHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHADSLETQTRWRETVLALFRRH
ARLPEAPKAGQEPLAVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTIYE

Nucleotide

• Length: 855 bp