Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 4770513..4771771 Replicon chromosome
Accession NZ_CP096953
Organism Pseudomonas aeruginosa strain NY5535

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag M2I95_RS22800 Protein ID WP_023109087.1
Coordinates 4770513..4771268 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag M2I95_RS22805 Protein ID WP_003086329.1
Coordinates 4771403..4771771 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2I95_RS22790 (M2I95_22660) 4765685..4768228 + 2544 WP_033876574.1 acyl-homoserine-lactone acylase QuiP -
M2I95_RS22795 (M2I95_22665) 4768383..4769744 - 1362 WP_003081943.1 DNA recombination protein RmuC -
M2I95_RS22800 (M2I95_22670) 4770513..4771268 - 756 WP_023109087.1 RES family NAD+ phosphorylase Toxin
M2I95_RS22805 (M2I95_22675) 4771403..4771771 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
M2I95_RS22810 (M2I95_22680) 4771844..4773130 - 1287 WP_054376095.1 FAD-binding oxidoreductase -
M2I95_RS22815 (M2I95_22685) 4773186..4774679 - 1494 WP_015648322.1 aldehyde dehydrogenase family protein -
M2I95_RS22820 (M2I95_22690) 4774854..4775330 + 477 WP_004353334.1 elongation factor GreAB -
M2I95_RS22825 (M2I95_22695) 4775333..4775608 - 276 WP_023088486.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28264.40 Da        Isoelectric Point: 7.7294

>T244257 WP_023109087.1 NZ_CP096953:c4771268-4770513 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGTAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT244257 WP_003086329.1 NZ_CP096953:c4771771-4771403 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References