244254

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 179323..179828 Replicon chromosome
Accession NZ_CP096953
Organism Pseudomonas aeruginosa strain NY5535

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag M2I95_RS00805 Protein ID WP_003083773.1
Coordinates 179323..179604 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag M2I95_RS00810 Protein ID WP_003083775.1
Coordinates 179601..179828 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2I95_RS00780 (M2I95_00780) 174574..175923 + 1350 WP_003119513.1 C4-dicarboxylate transporter DctA -
M2I95_RS00785 (M2I95_00785) 175972..176658 + 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
M2I95_RS00790 (M2I95_00790) 176759..177493 + 735 WP_003117208.1 GntR family transcriptional regulator -
M2I95_RS00795 (M2I95_00795) 177673..178083 + 411 WP_003101225.1 aegerolysin family protein -
M2I95_RS00800 (M2I95_00800) 178115..179023 - 909 WP_023132709.1 LysR family transcriptional regulator -
M2I95_RS00805 (M2I95_00805) 179323..179604 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
M2I95_RS00810 (M2I95_00810) 179601..179828 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
M2I95_RS00815 (M2I95_00815) 180004..180624 - 621 WP_003101226.1 hypothetical protein -
M2I95_RS00820 (M2I95_00820) 180725..181225 + 501 WP_003101228.1 LEA type 2 family protein -
M2I95_RS00825 (M2I95_00825) 181298..181639 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
M2I95_RS00830 (M2I95_00830) 181721..183148 - 1428 WP_003083784.1 GABA permease -
M2I95_RS00835 (M2I95_00835) 183317..184810 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T244254 WP_003083773.1 NZ_CP096953:c179604-179323 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT244254 WP_003083775.1 NZ_CP096953:c179828-179601 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References