Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RHH
Location 15224..15774 Replicon plasmid pNY5532-NR
Accession NZ_CP096952
Organism Pseudomonas aeruginosa strain NY5532

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag M2I94_RS34950 Protein ID WP_033992330.1
Coordinates 15499..15774 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A6B1YL09
Locus tag M2I94_RS34945 Protein ID WP_019727126.1
Coordinates 15224..15499 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2I94_RS34905 (M2I94_34800) 11551..11814 - 264 WP_124171349.1 hypothetical protein -
M2I94_RS34910 (M2I94_34805) 11828..12100 - 273 WP_084929133.1 hypothetical protein -
M2I94_RS34915 (M2I94_34810) 12097..12348 - 252 WP_058159039.1 hypothetical protein -
M2I94_RS34920 (M2I94_34815) 12408..12659 + 252 WP_019727135.1 hypothetical protein -
M2I94_RS34925 (M2I94_34820) 12710..12958 - 249 WP_033992320.1 hypothetical protein -
M2I94_RS34930 (M2I94_34825) 13577..13885 - 309 WP_058159041.1 TrfB-related DNA-binding protein -
M2I94_RS34935 (M2I94_34830) 14209..14502 - 294 WP_033992327.1 hypothetical protein -
M2I94_RS34940 (M2I94_34835) 14563..14949 - 387 WP_034019111.1 hypothetical protein -
M2I94_RS34945 (M2I94_34840) 15224..15499 + 276 WP_019727126.1 ribbon-helix-helix domain-containing protein Antitoxin
M2I94_RS34950 (M2I94_34845) 15499..15774 + 276 WP_033992330.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M2I94_RS34955 (M2I94_34850) 15864..16280 - 417 WP_033992331.1 hypothetical protein -
M2I94_RS34960 (M2I94_34855) 16261..17436 - 1176 WP_190306874.1 hypothetical protein -
M2I94_RS34965 (M2I94_34860) 17493..17972 - 480 WP_033995621.1 hypothetical protein -
M2I94_RS34970 (M2I94_34865) 18425..18721 - 297 WP_160511451.1 hypothetical protein -
M2I94_RS34975 (M2I94_34870) 18747..19163 - 417 WP_269762071.1 hypothetical protein -
M2I94_RS34980 (M2I94_34875) 19168..20250 - 1083 WP_033992858.1 DNA-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..56517 56517


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(11-48)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10679.28 Da        Isoelectric Point: 8.0246

>T244253 WP_033992330.1 NZ_CP096952:15499-15774 [Pseudomonas aeruginosa]
MELKWTSKGLSDVARLYEFLATVNKAAAARTVQQLTSAPTALLTNPRLGERLEEFEPRDVRRILIGHYEMRYEILDSCVY
VLRLWHTREDR

Download         Length: 276 bp

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10142.32 Da        Isoelectric Point: 4.8433

>AT244253 WP_019727126.1 NZ_CP096952:15224-15499 [Pseudomonas aeruginosa]
MSTAAKPTRTVTAHVPVDLAERVDAIAERLERSKNWIVRQALSAWIDQEDERSRLTREALDDVDAGRVVDHQAVQAWAES
LGTDSPLPVPR

Download         Length: 276 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A6B1YL09

References