Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | slvAT/RES(toxin) |
| Location | 148889..149805 | Replicon | plasmid pNY5532-OXA |
| Accession | NZ_CP096951 | ||
| Organism | Pseudomonas aeruginosa strain NY5532 | ||
Toxin (Protein)
| Gene name | slvT | Uniprot ID | A0A2L1KI32 |
| Locus tag | M2I94_RS33170 | Protein ID | WP_019437783.1 |
| Coordinates | 148889..149413 (-) | Length | 175 a.a. |
Antitoxin (Protein)
| Gene name | slvA | Uniprot ID | A0A2L1KH13 |
| Locus tag | M2I94_RS33175 | Protein ID | WP_019437782.1 |
| Coordinates | 149410..149805 (-) | Length | 132 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| M2I94_RS33150 (M2I94_33055) | 144210..145355 | + | 1146 | WP_021263240.1 | glycerate kinase | - |
| M2I94_RS33155 (M2I94_33060) | 145775..145966 | - | 192 | WP_019437785.1 | hypothetical protein | - |
| M2I94_RS33160 (M2I94_33065) | 146341..147396 | + | 1056 | WP_109392701.1 | prepilin-type N-terminal cleavage/methylation domain-containing protein | - |
| M2I94_RS33165 (M2I94_33070) | 147593..148843 | + | 1251 | WP_019437784.1 | TerD family protein | - |
| M2I94_RS33170 (M2I94_33075) | 148889..149413 | - | 525 | WP_019437783.1 | RES family NAD+ phosphorylase | Toxin |
| M2I94_RS33175 (M2I94_33080) | 149410..149805 | - | 396 | WP_019437782.1 | hypothetical protein | Antitoxin |
| M2I94_RS33180 (M2I94_33085) | 150389..152272 | - | 1884 | WP_223819158.1 | helicase | - |
| M2I94_RS33185 (M2I94_33090) | 152472..152726 | + | 255 | WP_021263738.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | aac(3)-IId / sul1 / qacE / blaOXA-246 / cmlA1 / aadA13 / aac(6')-IIa | - | 1..407607 | 407607 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 175 a.a. Molecular weight: 19052.57 Da Isoelectric Point: 4.5535
>T244252 WP_019437783.1 NZ_CP096951:c149413-148889 [Pseudomonas aeruginosa]
MKIIGVQDLPCYRMHTPKWSVAPTSGAGAATQGGRVNRKGLEALYLSLESATAIAEFQQASAFLPPGLLISYSLSLDRVI
DFTGGYNDTWAPIWQDFFCDWRKIRFNDGVEPPSWIIGDLAIEADCAGILFESVANPGGRNLVLFTDQLPVHGNIVVNDP
RGDLPTDQSSWTRP
MKIIGVQDLPCYRMHTPKWSVAPTSGAGAATQGGRVNRKGLEALYLSLESATAIAEFQQASAFLPPGLLISYSLSLDRVI
DFTGGYNDTWAPIWQDFFCDWRKIRFNDGVEPPSWIIGDLAIEADCAGILFESVANPGGRNLVLFTDQLPVHGNIVVNDP
RGDLPTDQSSWTRP
Download Length: 525 bp
Antitoxin
Download Length: 132 a.a. Molecular weight: 14753.87 Da Isoelectric Point: 7.2048
>AT244252 WP_019437782.1 NZ_CP096951:c149805-149410 [Pseudomonas aeruginosa]
MASKAVLELRPTNFAGLMDALKEVNRVMFSPERFLKVFSMDQQTLALRAHVHRNTVRNAPESEKVQAYIRDSVKVLRAVT
DMGTDVTNAIFWFKNEPLSTFGYKTAEEVVSEGKTEQLIAFLQSWEAGAQG
MASKAVLELRPTNFAGLMDALKEVNRVMFSPERFLKVFSMDQQTLALRAHVHRNTVRNAPESEKVQAYIRDSVKVLRAVT
DMGTDVTNAIFWFKNEPLSTFGYKTAEEVVSEGKTEQLIAFLQSWEAGAQG
Download Length: 396 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2L1KI32 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2L1KH13 |