Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 5531951..5532537 Replicon chromosome
Accession NZ_CP096950
Organism Pseudomonas aeruginosa strain NY5532

Toxin (Protein)


Gene name PumA Uniprot ID G8CP73
Locus tag M2I94_RS26150 Protein ID WP_003120987.1
Coordinates 5532238..5532537 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag M2I94_RS26145 Protein ID WP_003448662.1
Coordinates 5531951..5532241 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2I94_RS26130 (M2I94_26040) 5527527..5529422 + 1896 WP_267671723.1 hypothetical protein -
M2I94_RS26135 (M2I94_26045) 5529419..5531395 + 1977 WP_128666225.1 DEAD/DEAH box helicase -
M2I94_RS26140 (M2I94_26050) 5531536..5531880 + 345 WP_003448665.1 hypothetical protein -
M2I94_RS26145 (M2I94_26055) 5531951..5532241 - 291 WP_003448662.1 putative addiction module antidote protein Antitoxin
M2I94_RS26150 (M2I94_26060) 5532238..5532537 - 300 WP_003120987.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M2I94_RS26155 (M2I94_26065) 5532739..5533425 + 687 WP_283859371.1 PilL N-terminal domain-containing protein -
M2I94_RS26160 (M2I94_26070) 5533436..5533864 + 429 WP_283859372.1 toxin co-regulated pilus biosynthesis Q family protein -
M2I94_RS26165 (M2I94_26075) 5533864..5535573 + 1710 WP_283859373.1 PilN family type IVB pilus formation outer membrane protein -
M2I94_RS26170 (M2I94_26080) 5535577..5536902 + 1326 WP_003149518.1 type 4b pilus protein PilO2 -
M2I94_RS26175 (M2I94_26085) 5536892..5537425 + 534 WP_003099760.1 type IV pilus biogenesis protein PilP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 5500526..5587779 87253


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-96)

Antitoxin

Cro/C1-type helix-turn-helix domain

(47-90)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11133.88 Da        Isoelectric Point: 10.4495

>T244250 WP_003120987.1 NZ_CP096950:c5532537-5532238 [Pseudomonas aeruginosa]
MVEVKQTATFMAWESKLKDRRAKAVIAARIFRLANGLPGDVSPVGQGVSELRIHYGPGYRVYFQQRGTEIVILLCGGDKS
SQARDIEMAKRLANEWRPQ

Download         Length: 300 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10394.91 Da        Isoelectric Point: 4.7527

>AT244250 WP_003448662.1 NZ_CP096950:c5532241-5531951 [Pseudomonas aeruginosa]
MTEQIYDYDPAQALDSPEAMALFIADALDTGDTAYIAKAMGVVARAKGMTELAKETGLAREQLYKSFSERGNPTLKTMLA
VMRALGVDLTARPHAQ

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G8CP73

Antitoxin

Source ID Structure

References