244249

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 4615149..4616407 Replicon chromosome
Accession NZ_CP096950
Organism Pseudomonas aeruginosa strain NY5532

Toxin (Protein)


Gene name - Uniprot ID Q9I4U4
Locus tag M2I94_RS21620 Protein ID WP_003112528.1
Coordinates 4615149..4615904 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag M2I94_RS21625 Protein ID WP_003086329.1
Coordinates 4616039..4616407 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2I94_RS21610 (M2I94_21525) 4610322..4612865 + 2544 WP_003112526.1 acyl-homoserine-lactone acylase QuiP -
M2I94_RS21615 (M2I94_21530) 4613020..4614381 - 1362 WP_010895536.1 DNA recombination protein RmuC -
M2I94_RS21620 (M2I94_21535) 4615149..4615904 - 756 WP_003112528.1 RES family NAD+ phosphorylase Toxin
M2I94_RS21625 (M2I94_21540) 4616039..4616407 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
M2I94_RS21630 (M2I94_21545) 4616480..4617766 - 1287 WP_003112529.1 FAD-binding oxidoreductase -
M2I94_RS21635 (M2I94_21550) 4617822..4619315 - 1494 WP_003086325.1 aldehyde dehydrogenase family protein -
M2I94_RS21640 (M2I94_21555) 4619490..4619966 + 477 WP_003112531.1 hypothetical protein -
M2I94_RS21645 (M2I94_21560) 4619969..4620244 - 276 WP_010793902.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28278.42 Da        Isoelectric Point: 7.7294

>T244249 WP_003112528.1 NZ_CP096950:c4615904-4615149 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMVVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT244249 WP_003086329.1 NZ_CP096950:c4616407-4616039 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9I4U4

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References