Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3682508..3683729 Replicon chromosome
Accession NZ_CP096950
Organism Pseudomonas aeruginosa strain NY5532

Toxin (Protein)


Gene name vapC Uniprot ID A0A0C7CS07
Locus tag M2I94_RS17195 Protein ID WP_003102740.1
Coordinates 3683151..3683729 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag M2I94_RS17190 Protein ID WP_003088112.1
Coordinates 3682508..3683062 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2I94_RS17165 (M2I94_17090) 3678076..3678627 + 552 WP_004343115.1 XRE family transcriptional regulator -
M2I94_RS17170 (M2I94_17095) 3678624..3679022 - 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
M2I94_RS17175 (M2I94_17100) 3679035..3679358 - 324 WP_003102734.1 multidrug efflux SMR transporter -
M2I94_RS17180 (M2I94_17105) 3679689..3680150 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
M2I94_RS17185 (M2I94_17110) 3680155..3682350 + 2196 WP_010794059.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
M2I94_RS17190 (M2I94_17115) 3682508..3683062 + 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
M2I94_RS17195 (M2I94_17120) 3683151..3683729 + 579 WP_003102740.1 HD domain-containing protein Toxin
M2I94_RS17200 (M2I94_17125) 3683838..3685025 - 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
M2I94_RS17205 (M2I94_17130) 3685015..3687186 - 2172 WP_003114950.1 type I secretion system permease/ATPase -
M2I94_RS17210 (M2I94_17135) 3687176..3688453 - 1278 WP_003102743.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21869.70 Da        Isoelectric Point: 5.3655

>T244248 WP_003102740.1 NZ_CP096950:3683151-3683729 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT244248 WP_003088112.1 NZ_CP096950:3682508-3683062 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C7CS07

Antitoxin

Source ID Structure

References