244247

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 2555094..2555610 Replicon chromosome
Accession NZ_CP096950
Organism Pseudomonas aeruginosa strain NY5532

Toxin (Protein)


Gene name relE Uniprot ID A0A3R8UIH5
Locus tag M2I94_RS12420 Protein ID WP_025297453.1
Coordinates 2555329..2555610 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A3R8UIM7
Locus tag M2I94_RS12415 Protein ID WP_025297454.1
Coordinates 2555094..2555339 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2I94_RS12400 (M2I94_12365) 2551933..2552964 - 1032 WP_283859411.1 WYL domain-containing protein -
M2I94_RS12405 (M2I94_12370) 2553003..2554165 + 1163 WP_176704564.1 IS3 family transposase -
M2I94_RS12410 (M2I94_12375) 2554405..2554659 - 255 WP_153574174.1 hypothetical protein -
M2I94_RS12415 (M2I94_12380) 2555094..2555339 + 246 WP_025297454.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
M2I94_RS12420 (M2I94_12385) 2555329..2555610 + 282 WP_025297453.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M2I94_RS12425 (M2I94_12390) 2556016..2556597 - 582 WP_033976848.1 plasmid pRiA4b ORF-3 family protein -
M2I94_RS12430 (M2I94_12395) 2556611..2557486 - 876 WP_033976847.1 WYL domain-containing protein -
M2I94_RS12435 (M2I94_12400) 2557616..2559196 + 1581 WP_070147860.1 DNA recombination protein RmuC -
M2I94_RS12440 (M2I94_12405) 2559220..2559867 + 648 WP_033976844.1 peptidase M15 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2542296..2586779 44483


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-81)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(10-71)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10824.61 Da        Isoelectric Point: 10.6249

>T244247 WP_025297453.1 NZ_CP096950:2555329-2555610 [Pseudomonas aeruginosa]
MTYELEFLPSALKEWQKLGHTVREQIKKKLRERLDNPKVQADALRDMPGHYKIKLRASGYRLVYRVEDERVVVVVVAVGK
RERGAAYQSAKGR

Download         Length: 282 bp

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8797.21 Da        Isoelectric Point: 4.2550

>AT244247 WP_025297454.1 NZ_CP096950:2555094-2555339 [Pseudomonas aeruginosa]
MQSILADVAVSVSELKKNPSGILAGAGGMPVAVLNHNRVMGYMVPAELYEQMMERLDDLELVEIVKARSGEESVPVRLDD
L

Download         Length: 246 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3R8UIH5

Antitoxin

Source ID Structure
AlphaFold DB A0A3R8UIM7

References