244245

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1651280..1652975 Replicon chromosome
Accession NZ_CP096950
Organism Pseudomonas aeruginosa strain NY5532

Toxin (Protein)


Gene name doc Uniprot ID Q9HYA0
Locus tag M2I94_RS07800 Protein ID WP_003112901.1
Coordinates 1651280..1652149 (+) Length 290 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID Q9HYA1
Locus tag M2I94_RS07805 Protein ID WP_003112902.1
Coordinates 1652142..1652975 (+) Length 278 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2I94_RS07775 (M2I94_07765) 1647288..1648139 + 852 WP_003130104.1 ABC transporter ATP-binding protein -
M2I94_RS07780 (M2I94_07770) 1648180..1649187 + 1008 WP_003112897.1 ABC transporter substrate-binding protein -
M2I94_RS07785 (M2I94_07775) 1649184..1649960 + 777 WP_003112898.1 ABC transporter permease -
M2I94_RS07790 (M2I94_07780) 1649966..1650727 + 762 WP_003112899.1 SDR family oxidoreductase -
M2I94_RS07795 (M2I94_07785) 1650741..1651271 + 531 WP_003112900.1 cupin domain-containing protein -
M2I94_RS07800 (M2I94_07790) 1651280..1652149 + 870 WP_003112901.1 alpha/beta hydrolase Toxin
M2I94_RS07805 (M2I94_07795) 1652142..1652975 + 834 WP_003112902.1 IclR family transcriptional regulator Antitoxin
M2I94_RS07810 (M2I94_07800) 1652962..1653759 + 798 WP_003112903.1 SDR family oxidoreductase -
M2I94_RS07815 (M2I94_07805) 1653752..1655434 + 1683 WP_003130114.1 thiamine pyrophosphate-binding protein -
M2I94_RS07820 (M2I94_07810) 1655445..1656248 + 804 WP_003130116.1 aspartate dehydrogenase -
M2I94_RS07825 (M2I94_07815) 1656260..1657744 + 1485 WP_003453562.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(41-272)

Antitoxin

Transcription regulator IclR, N-terminal

(16-66)


Sequences

Toxin        


Download         Length: 290 a.a.        Molecular weight: 30403.60 Da        Isoelectric Point: 6.5894

>T244245 WP_003112901.1 NZ_CP096950:1651280-1652149 [Pseudomonas aeruginosa]
MNMAQTHTPVPNLQQRFPERLVQLADGAQLAIRECGQGPVVVLLHGIGSGSASWLHCAQRLAAGNRVIAWDAPGYGLSTP
LPPARPKACDYAACLELLLDALGVESCLLVGHSLGALMATAYAAGIGAARVRRLVLLSPARGYGAAELRDSGAQVRRQRL
ENLERFGIDGMASERTARLLGRNPSEEALAWVRWNMARLNPEGYRQAVELLCGDDLLGNGQPAAPCEVHCGEDDGITTPE
SCGAIARQLGASFSSIPGAGHASPIEQPEVVAGRIGHAQRLSLEGTANG

Download         Length: 870 bp

Antitoxin


Download         Length: 278 a.a.        Molecular weight: 30877.26 Da        Isoelectric Point: 5.7725

>AT244245 WP_003112902.1 NZ_CP096950:1652142-1652975 [Pseudomonas aeruginosa]
MDKSDDSQDKYIVPGLERGLLLLCEFSRKDRTLTAPELARRLKLPRSTIFRLLTTLEAMGFVTRNGNEYRLGMAVLRLGF
EYLASLELTELGQPLLNRLCDEIRYPCNLVVRDGRSIVYVAKVSPSTPLSSSVNVGTRLPAHATVLGRILLQDLSLGELR
ELYPEEQLEQFSPNTPRSVLELFDMVQGDRQRGFVQGEGFFEASISTVAAPVRDHSGRVIAAMGATIAAGHIDPERIEGL
VSRVRSSADELSYLLDYRADGQDNVTPIFRSRPHETV

Download         Length: 834 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9HYA0

Antitoxin

Source ID Structure
AlphaFold DB Q9HYA1

References