Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 4846716..4847974 Replicon chromosome
Accession NZ_CP096946
Organism Pseudomonas aeruginosa strain NY5530

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag M2I93_RS22750 Protein ID WP_023109087.1
Coordinates 4846716..4847471 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag M2I93_RS22755 Protein ID WP_003086329.1
Coordinates 4847606..4847974 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2I93_RS22740 (M2I93_22695) 4841888..4844431 + 2544 WP_033876574.1 acyl-homoserine-lactone acylase QuiP -
M2I93_RS22745 (M2I93_22700) 4844586..4845947 - 1362 WP_003081943.1 DNA recombination protein RmuC -
M2I93_RS22750 (M2I93_22705) 4846716..4847471 - 756 WP_023109087.1 RES family NAD+ phosphorylase Toxin
M2I93_RS22755 (M2I93_22710) 4847606..4847974 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
M2I93_RS22760 (M2I93_22715) 4848047..4849333 - 1287 WP_054376095.1 FAD-binding oxidoreductase -
M2I93_RS22765 (M2I93_22720) 4849389..4850882 - 1494 WP_015648322.1 aldehyde dehydrogenase family protein -
M2I93_RS22770 (M2I93_22725) 4851057..4851533 + 477 WP_004353334.1 elongation factor GreAB -
M2I93_RS22775 (M2I93_22730) 4851536..4851811 - 276 WP_023088486.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28264.40 Da        Isoelectric Point: 7.7294

>T244242 WP_023109087.1 NZ_CP096946:c4847471-4846716 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGTAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT244242 WP_003086329.1 NZ_CP096946:c4847974-4847606 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References