Detailed information of TA system TA244240

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Acetyltransf_4(toxin)
• Location: 2025011..2026519
• Replicon: chromosome
• Accession: NZ_CP096946
• Organism: Pseudomonas aeruginosa strain NY5530

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: M2I93_RS09825
• Protein ID: WP_012613851.1
• Coordinates: 2025011..2025598 (+)
• Length: 196 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: M2I93_RS09830
• Protein ID: WP_012613852.1
• Coordinates: 2025665..2026519 (+)
• Length: 285 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M2I93_RS09820 (M2I93_09805)	2021266..2024745	-	3480	WP_003117605.1	PAS domain-containing hybrid sensor histidine kinase/response regulator	-
M2I93_RS09825 (M2I93_09810)	2025011..2025598	+	588	WP_012613851.1	GNAT family protein	Toxin
M2I93_RS09830 (M2I93_09815)	2025665..2026519	+	855	WP_012613852.1	AraC family transcriptional regulator	Antitoxin
M2I93_RS09835 (M2I93_09820)	2026616..2028781	+	2166	WP_003091606.1	TonB-dependent receptor family protein	-
M2I93_RS09840 (M2I93_09825)	2028956..2030830	+	1875	WP_023128709.1	MFS transporter	-
M2I93_RS09845 (M2I93_09830)	2030891..2031100	-	210	WP_003091604.1	cold-shock protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (20-152)

Antitoxin

• AraC-type arabinose-binding/dimerisation domain (19-151)

Sequences

Toxin

Protein

• Length: 196 a.a.
• Molecular weight: 21929.29 Da
• Isoelectric Point: 9.8676

>T244240 WP_012613851.1 NZ_CP096946:2025011-2025598 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAVLEASFTG

Nucleotide

• Length: 588 bp

Antitoxin

Protein

• Length: 285 a.a.
• Molecular weight: 31959.27 Da
• Isoelectric Point: 7.3276

>AT244240 WP_012613852.1 NZ_CP096946:2025665-2026519 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHADSLETQTRWRETVLALFRRH
ARLPEAPKAGQEPLPVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTIYE

Nucleotide

• Length: 855 bp