244237

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PfiT-PfiA/ParE(toxin)
Location 5137819..5138427 Replicon chromosome
Accession NZ_CP096945
Organism Pseudomonas aeruginosa strain NY5525

Toxin (Protein)


Gene name PfiT Uniprot ID A0A1B1XUZ2
Locus tag M2I92_RS24785 Protein ID WP_003123043.1
Coordinates 5137819..5138166 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name PfiA Uniprot ID A0A0B0C355
Locus tag M2I92_RS24790 Protein ID WP_003114155.1
Coordinates 5138176..5138427 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2I92_RS24755 (M2I92_24675) 5133238..5133450 + 213 WP_015503462.1 cysteine-rich CWC family protein -
M2I92_RS24760 (M2I92_24680) 5133450..5134142 + 693 WP_003085458.1 16S rRNA pseudouridine(516) synthase -
M2I92_RS24765 (M2I92_24685) 5134278..5135321 + 1044 WP_003134392.1 L,D-transpeptidase -
M2I92_RS24770 (M2I92_24690) 5135401..5136138 + 738 WP_003085453.1 murein L,D-transpeptidase catalytic domain family protein -
M2I92_RS24775 (M2I92_24695) 5136590..5137492 + 903 WP_003163340.1 (R)-3-hydroxydecanoyl-ACP:CoA transacylase -
M2I92_RS24785 (M2I92_24705) 5137819..5138166 - 348 WP_003123043.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M2I92_RS24790 (M2I92_24710) 5138176..5138427 - 252 WP_003114155.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
M2I92_RS24795 (M2I92_24715) 5138641..5139624 - 984 WP_003114154.1 tyrosine-type recombinase/integrase -
M2I92_RS24800 (M2I92_24720) 5139624..5140916 - 1293 WP_003123045.1 hypothetical protein -
M2I92_RS24805 (M2I92_24725) 5141146..5142420 - 1275 WP_003151267.1 zonular occludens toxin family protein -
M2I92_RS24810 (M2I92_24730) 5142424..5142780 - 357 WP_003114150.1 DUF2523 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage catB7 - 5137819..5158413 20594


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-100)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12990.74 Da        Isoelectric Point: 4.4212

>T244237 WP_003123043.1 NZ_CP096945:c5138166-5137819 [Pseudomonas aeruginosa]
MSPVVIRFTDTAEQSIEDQVHHLAPFQGEQAAFQSVLSLLDEIEEKISLAPKGYPVSQQASLLGVLSYRELNTGPYRVFY
EFHEEQGEAAVILVLRQKQSVEQQLIRYCLVGPIE

Download         Length: 348 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9442.79 Da        Isoelectric Point: 9.4808

>AT244237 WP_003114155.1 NZ_CP096945:c5138427-5138176 [Pseudomonas aeruginosa]
MRVETISYLKRHAADLDLSEPMVVTQNGVPAYVVESYAERKQRDEAIALVKLLAIGSRQYAEGKHRSVDDLKARLSRRFA
QPE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B1XUZ2

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0C355

References