Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 4699284..4700542 Replicon chromosome
Accession NZ_CP096945
Organism Pseudomonas aeruginosa strain NY5525

Toxin (Protein)


Gene name - Uniprot ID Q9I4U4
Locus tag M2I92_RS22540 Protein ID WP_003112528.1
Coordinates 4699284..4700039 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag M2I92_RS22545 Protein ID WP_003086329.1
Coordinates 4700174..4700542 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2I92_RS22530 (M2I92_22460) 4694456..4696999 + 2544 WP_031630217.1 acyl-homoserine-lactone acylase QuiP -
M2I92_RS22535 (M2I92_22465) 4697154..4698515 - 1362 WP_003120632.1 DNA recombination protein RmuC -
M2I92_RS22540 (M2I92_22470) 4699284..4700039 - 756 WP_003112528.1 RES family NAD+ phosphorylase Toxin
M2I92_RS22545 (M2I92_22475) 4700174..4700542 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
M2I92_RS22550 (M2I92_22480) 4700615..4701901 - 1287 WP_003163134.1 FAD-binding oxidoreductase -
M2I92_RS22555 (M2I92_22485) 4701957..4703450 - 1494 WP_003086325.1 aldehyde dehydrogenase family protein -
M2I92_RS22560 (M2I92_22490) 4703625..4704101 + 477 WP_003112531.1 hypothetical protein -
M2I92_RS22565 (M2I92_22495) 4704104..4704379 - 276 WP_023088486.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28278.42 Da        Isoelectric Point: 7.7294

>T244235 WP_003112528.1 NZ_CP096945:c4700039-4699284 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMVVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT244235 WP_003086329.1 NZ_CP096945:c4700542-4700174 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9I4U4

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References