Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/- |
| Location | 3607906..3609127 | Replicon | chromosome |
| Accession | NZ_CP096945 | ||
| Organism | Pseudomonas aeruginosa strain NY5525 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | - |
| Locus tag | M2I92_RS17055 | Protein ID | WP_003162864.1 |
| Coordinates | 3608549..3609127 (+) | Length | 193 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | - |
| Locus tag | M2I92_RS17050 | Protein ID | WP_003088112.1 |
| Coordinates | 3607906..3608460 (+) | Length | 185 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| M2I92_RS17025 (M2I92_16970) | 3603474..3604025 | + | 552 | WP_003102727.1 | XRE family transcriptional regulator | - |
| M2I92_RS17030 (M2I92_16975) | 3604022..3604420 | - | 399 | WP_003088123.1 | NADH-quinone oxidoreductase subunit A | - |
| M2I92_RS17035 (M2I92_16980) | 3604433..3604756 | - | 324 | WP_003102734.1 | multidrug efflux SMR transporter | - |
| M2I92_RS17040 (M2I92_16985) | 3605087..3605548 | + | 462 | WP_003102736.1 | (2Fe-2S)-binding protein | - |
| M2I92_RS17045 (M2I92_16990) | 3605553..3607748 | + | 2196 | WP_004349295.1 | xanthine dehydrogenase family protein molybdopterin-binding subunit | - |
| M2I92_RS17050 (M2I92_16995) | 3607906..3608460 | + | 555 | WP_003088112.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| M2I92_RS17055 (M2I92_17000) | 3608549..3609127 | + | 579 | WP_003162864.1 | HD domain-containing protein | Toxin |
| M2I92_RS17060 (M2I92_17005) | 3609235..3610422 | - | 1188 | WP_003102741.1 | HlyD family efflux transporter periplasmic adaptor subunit | - |
| M2I92_RS17065 (M2I92_17010) | 3610412..3612583 | - | 2172 | WP_003114950.1 | type I secretion system permease/ATPase | - |
| M2I92_RS17070 (M2I92_17015) | 3612573..3613850 | - | 1278 | WP_003102743.1 | TolC family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 193 a.a. Molecular weight: 21911.78 Da Isoelectric Point: 5.3655
>T244234 WP_003162864.1 NZ_CP096945:3608549-3609127 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDILRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAVRRDA
MSLELLSNRLEFLREAERLKDILRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAVRRDA
Download Length: 579 bp
Antitoxin
Download Length: 185 a.a. Molecular weight: 20454.63 Da Isoelectric Point: 8.1590
>AT244234 WP_003088112.1 NZ_CP096945:3607906-3608460 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL
Download Length: 555 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|