Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 1993662..1995170 Replicon chromosome
Accession NZ_CP096945
Organism Pseudomonas aeruginosa strain NY5525

Toxin (Protein)


Gene name - Uniprot ID Q9HYX1
Locus tag M2I92_RS09420 Protein ID WP_003119682.1
Coordinates 1993662..1994249 (+) Length 196 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag M2I92_RS09425 Protein ID WP_031671186.1
Coordinates 1994316..1995170 (+) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2I92_RS09415 (M2I92_09400) 1989917..1993396 - 3480 WP_003117605.1 PAS domain-containing hybrid sensor histidine kinase/response regulator -
M2I92_RS09420 (M2I92_09405) 1993662..1994249 + 588 WP_003119682.1 GNAT family protein Toxin
M2I92_RS09425 (M2I92_09410) 1994316..1995170 + 855 WP_031671186.1 AraC family transcriptional regulator Antitoxin
M2I92_RS09430 (M2I92_09415) 1995267..1997432 + 2166 WP_003115567.1 TonB-dependent receptor family protein -
M2I92_RS09435 (M2I92_09420) 1997607..1999481 + 1875 WP_010793244.1 MFS transporter -
M2I92_RS09440 (M2I92_09425) 1999542..1999751 - 210 WP_003091604.1 cold-shock protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(20-152)

Antitoxin

AraC-type arabinose-binding/dimerisation domain

(19-151)


Sequences

Toxin        


Download         Length: 196 a.a.        Molecular weight: 21901.23 Da        Isoelectric Point: 9.8676

>T244233 WP_003119682.1 NZ_CP096945:1993662-1994249 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAALEASFTG

Download         Length: 588 bp

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31901.23 Da        Isoelectric Point: 7.5295

>AT244233 WP_031671186.1 NZ_CP096945:1994316-1995170 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHAGSLETQTRWRETVLALFRRH
ARLPEAPKAGQEPLPVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTIYE

Download         Length: 855 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 1YRE
PDB 8GXJ

Antitoxin

Source ID Structure

References