Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 156446..156951 Replicon chromosome
Accession NZ_CP096945
Organism Pseudomonas aeruginosa strain NY5525

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag M2I92_RS00735 Protein ID WP_003083773.1
Coordinates 156446..156727 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag M2I92_RS00740 Protein ID WP_003083775.1
Coordinates 156724..156951 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2I92_RS00710 (M2I92_00710) 151697..153046 + 1350 WP_003142411.1 C4-dicarboxylate transporter DctA -
M2I92_RS00715 (M2I92_00715) 153095..153781 + 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
M2I92_RS00720 (M2I92_00720) 153882..154616 + 735 WP_003117208.1 GntR family transcriptional regulator -
M2I92_RS00725 (M2I92_00725) 154796..155206 + 411 WP_003101225.1 aegerolysin family protein -
M2I92_RS00730 (M2I92_00730) 155238..156146 - 909 WP_003083769.1 LysR family transcriptional regulator -
M2I92_RS00735 (M2I92_00735) 156446..156727 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
M2I92_RS00740 (M2I92_00740) 156724..156951 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
M2I92_RS00745 (M2I92_00745) 157127..157747 - 621 WP_003101226.1 hypothetical protein -
M2I92_RS00750 (M2I92_00750) 157848..158348 + 501 WP_034040605.1 LEA type 2 family protein -
M2I92_RS00755 (M2I92_00755) 158421..158762 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
M2I92_RS00760 (M2I92_00760) 158844..160271 - 1428 WP_003083784.1 GABA permease -
M2I92_RS00765 (M2I92_00765) 160440..161933 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T244232 WP_003083773.1 NZ_CP096945:c156727-156446 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT244232 WP_003083775.1 NZ_CP096945:c156951-156724 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References