244229

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 4542040..4543735 Replicon chromosome
Accession NZ_CP096942
Organism Pseudomonas aeruginosa strain NY5524

Toxin (Protein)


Gene name doc Uniprot ID Q9HYA0
Locus tag M2I87_RS21830 Protein ID WP_003112901.1
Coordinates 4542866..4543735 (-) Length 290 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID Q9HYA1
Locus tag M2I87_RS21825 Protein ID WP_003112902.1
Coordinates 4542040..4542873 (-) Length 278 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2I87_RS21805 (M2I87_21690) 4537271..4538755 - 1485 WP_003453562.1 aldehyde dehydrogenase -
M2I87_RS21810 (M2I87_21695) 4538767..4539570 - 804 WP_003130116.1 aspartate dehydrogenase -
M2I87_RS21815 (M2I87_21700) 4539581..4541263 - 1683 WP_003130114.1 thiamine pyrophosphate-binding protein -
M2I87_RS21820 (M2I87_21705) 4541256..4542053 - 798 WP_003112903.1 SDR family oxidoreductase -
M2I87_RS21825 (M2I87_21710) 4542040..4542873 - 834 WP_003112902.1 IclR family transcriptional regulator Antitoxin
M2I87_RS21830 (M2I87_21715) 4542866..4543735 - 870 WP_003112901.1 alpha/beta hydrolase Toxin
M2I87_RS21835 (M2I87_21720) 4543744..4544274 - 531 WP_003112900.1 cupin domain-containing protein -
M2I87_RS21840 (M2I87_21725) 4544288..4545049 - 762 WP_003112899.1 SDR family oxidoreductase -
M2I87_RS21845 (M2I87_21730) 4545055..4545831 - 777 WP_003112898.1 ABC transporter permease -
M2I87_RS21850 (M2I87_21735) 4545828..4546835 - 1008 WP_003112897.1 ABC transporter substrate-binding protein -
M2I87_RS21855 (M2I87_21740) 4546876..4547727 - 852 WP_003130104.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(41-272)

Antitoxin

Transcription regulator IclR, N-terminal

(16-66)


Sequences

Toxin        


Download         Length: 290 a.a.        Molecular weight: 30403.60 Da        Isoelectric Point: 6.5894

>T244229 WP_003112901.1 NZ_CP096942:c4543735-4542866 [Pseudomonas aeruginosa]
MNMAQTHTPVPNLQQRFPERLVQLADGAQLAIRECGQGPVVVLLHGIGSGSASWLHCAQRLAAGNRVIAWDAPGYGLSTP
LPPARPKACDYAACLELLLDALGVESCLLVGHSLGALMATAYAAGIGAARVRRLVLLSPARGYGAAELRDSGAQVRRQRL
ENLERFGIDGMASERTARLLGRNPSEEALAWVRWNMARLNPEGYRQAVELLCGDDLLGNGQPAAPCEVHCGEDDGITTPE
SCGAIARQLGASFSSIPGAGHASPIEQPEVVAGRIGHAQRLSLEGTANG

Download         Length: 870 bp

Antitoxin


Download         Length: 278 a.a.        Molecular weight: 30877.26 Da        Isoelectric Point: 5.7725

>AT244229 WP_003112902.1 NZ_CP096942:c4542873-4542040 [Pseudomonas aeruginosa]
MDKSDDSQDKYIVPGLERGLLLLCEFSRKDRTLTAPELARRLKLPRSTIFRLLTTLEAMGFVTRNGNEYRLGMAVLRLGF
EYLASLELTELGQPLLNRLCDEIRYPCNLVVRDGRSIVYVAKVSPSTPLSSSVNVGTRLPAHATVLGRILLQDLSLGELR
ELYPEEQLEQFSPNTPRSVLELFDMVQGDRQRGFVQGEGFFEASISTVAAPVRDHSGRVIAAMGATIAAGHIDPERIEGL
VSRVRSSADELSYLLDYRADGQDNVTPIFRSRPHETV

Download         Length: 834 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9HYA0

Antitoxin

Source ID Structure
AlphaFold DB Q9HYA1

References