Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 3640642..3641158 Replicon chromosome
Accession NZ_CP096942
Organism Pseudomonas aeruginosa strain NY5524

Toxin (Protein)


Gene name relE Uniprot ID A0A3R8UIH5
Locus tag M2I87_RS17215 Protein ID WP_025297453.1
Coordinates 3640642..3640923 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A3R8UIM7
Locus tag M2I87_RS17220 Protein ID WP_025297454.1
Coordinates 3640913..3641158 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2I87_RS17195 (M2I87_17105) 3636385..3637032 - 648 WP_033976844.1 peptidase M15 -
M2I87_RS17200 (M2I87_17110) 3637056..3638636 - 1581 WP_070147860.1 DNA recombination protein RmuC -
M2I87_RS17205 (M2I87_17115) 3638766..3639641 + 876 WP_033976847.1 WYL domain-containing protein -
M2I87_RS17210 (M2I87_17120) 3639655..3640236 + 582 WP_033976848.1 plasmid pRiA4b ORF-3 family protein -
M2I87_RS17215 (M2I87_17125) 3640642..3640923 - 282 WP_025297453.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M2I87_RS17220 (M2I87_17130) 3640913..3641158 - 246 WP_025297454.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
M2I87_RS17225 (M2I87_17135) 3641593..3641847 + 255 WP_153574174.1 hypothetical protein -
M2I87_RS17230 (M2I87_17140) 3642005..3643081 + 1077 WP_052156709.1 WYL domain-containing protein -
M2I87_RS17235 (M2I87_17145) 3643179..3645380 + 2202 WP_033976850.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3609163..3656448 47285


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-81)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(10-71)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10824.61 Da        Isoelectric Point: 10.6249

>T244227 WP_025297453.1 NZ_CP096942:c3640923-3640642 [Pseudomonas aeruginosa]
MTYELEFLPSALKEWQKLGHTVREQIKKKLRERLDNPKVQADALRDMPGHYKIKLRASGYRLVYRVEDERVVVVVVAVGK
RERGAAYQSAKGR

Download         Length: 282 bp

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8797.21 Da        Isoelectric Point: 4.2550

>AT244227 WP_025297454.1 NZ_CP096942:c3641158-3640913 [Pseudomonas aeruginosa]
MQSILADVAVSVSELKKNPSGILAGAGGMPVAVLNHNRVMGYMVPAELYEQMMERLDDLELVEIVKARSGEESVPVRLDD
L

Download         Length: 246 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3R8UIH5

Antitoxin

Source ID Structure
AlphaFold DB A0A3R8UIM7

References