Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 2293390..2294611 Replicon chromosome
Accession NZ_CP096942
Organism Pseudomonas aeruginosa strain NY5524

Toxin (Protein)


Gene name vapC Uniprot ID A0A0C7CS07
Locus tag M2I87_RS11365 Protein ID WP_003102740.1
Coordinates 2293390..2293968 (-) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag M2I87_RS11370 Protein ID WP_003088112.1
Coordinates 2294057..2294611 (-) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2I87_RS11350 (M2I87_11300) 2288666..2289943 + 1278 WP_003102743.1 TolC family protein -
M2I87_RS11355 (M2I87_11305) 2289933..2292104 + 2172 WP_003114950.1 type I secretion system permease/ATPase -
M2I87_RS11360 (M2I87_11310) 2292094..2293281 + 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
M2I87_RS11365 (M2I87_11315) 2293390..2293968 - 579 WP_003102740.1 HD domain-containing protein Toxin
M2I87_RS11370 (M2I87_11320) 2294057..2294611 - 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
M2I87_RS11375 (M2I87_11325) 2294769..2296964 - 2196 WP_010794059.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
M2I87_RS11380 (M2I87_11330) 2296969..2297430 - 462 WP_003102736.1 (2Fe-2S)-binding protein -
M2I87_RS11385 (M2I87_11335) 2297761..2298084 + 324 WP_003102734.1 multidrug efflux SMR transporter -
M2I87_RS11390 (M2I87_11340) 2298097..2298495 + 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
M2I87_RS11395 (M2I87_11345) 2298492..2299043 - 552 WP_004343115.1 XRE family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21869.70 Da        Isoelectric Point: 5.3655

>T244225 WP_003102740.1 NZ_CP096942:c2293968-2293390 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT244225 WP_003088112.1 NZ_CP096942:c2294611-2294057 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C7CS07

Antitoxin

Source ID Structure

References