Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 196690..197195 Replicon chromosome
Accession NZ_CP096942
Organism Pseudomonas aeruginosa strain NY5524

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag M2I87_RS00935 Protein ID WP_003083773.1
Coordinates 196690..196971 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag M2I87_RS00940 Protein ID WP_003083775.1
Coordinates 196968..197195 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2I87_RS00910 (M2I87_00905) 191941..193290 + 1350 WP_003142411.1 C4-dicarboxylate transporter DctA -
M2I87_RS00915 (M2I87_00910) 193339..194025 + 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
M2I87_RS00920 (M2I87_00915) 194126..194860 + 735 WP_003117208.1 GntR family transcriptional regulator -
M2I87_RS00925 (M2I87_00920) 195040..195450 + 411 WP_003101225.1 aegerolysin family protein -
M2I87_RS00930 (M2I87_00925) 195482..196390 - 909 WP_010793581.1 LysR family transcriptional regulator -
M2I87_RS00935 (M2I87_00930) 196690..196971 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
M2I87_RS00940 (M2I87_00935) 196968..197195 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
M2I87_RS00945 (M2I87_00940) 197371..197991 - 621 WP_003101226.1 hypothetical protein -
M2I87_RS00950 (M2I87_00945) 198092..198592 + 501 WP_003101228.1 LEA type 2 family protein -
M2I87_RS00955 (M2I87_00950) 198665..199006 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
M2I87_RS00960 (M2I87_00955) 199088..200515 - 1428 WP_003083784.1 GABA permease -
M2I87_RS00965 (M2I87_00960) 200684..202177 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T244223 WP_003083773.1 NZ_CP096942:c196971-196690 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT244223 WP_003083775.1 NZ_CP096942:c197195-196968 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References