244221

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 4776667..4777925 Replicon chromosome
Accession NZ_CP096941
Organism Pseudomonas aeruginosa strain NY5523

Toxin (Protein)


Gene name - Uniprot ID V6AJ34
Locus tag M2I88_RS22300 Protein ID WP_003086331.1
Coordinates 4776667..4777422 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag M2I88_RS22305 Protein ID WP_003086329.1
Coordinates 4777557..4777925 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2I88_RS22290 (M2I88_22230) 4771838..4774381 + 2544 WP_003086335.1 acyl-homoserine-lactone acylase QuiP -
M2I88_RS22295 (M2I88_22235) 4774536..4775897 - 1362 WP_003081943.1 DNA recombination protein RmuC -
M2I88_RS22300 (M2I88_22240) 4776667..4777422 - 756 WP_003086331.1 RES family NAD+ phosphorylase Toxin
M2I88_RS22305 (M2I88_22245) 4777557..4777925 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
M2I88_RS22310 (M2I88_22250) 4777998..4779284 - 1287 WP_003086327.1 FAD-binding oxidoreductase -
M2I88_RS22315 (M2I88_22255) 4779340..4780833 - 1494 WP_003086325.1 aldehyde dehydrogenase family protein -
M2I88_RS22320 (M2I88_22260) 4781008..4781484 + 477 WP_003086322.1 hypothetical protein -
M2I88_RS22325 (M2I88_22265) 4781487..4781762 - 276 WP_023098713.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28236.34 Da        Isoelectric Point: 7.7294

>T244221 WP_003086331.1 NZ_CP096941:c4777422-4776667 [Pseudomonas aeruginosa]
VSEIWRQCKGERHVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT244221 WP_003086329.1 NZ_CP096941:c4777925-4777557 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6AJ34

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References