244220

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 4213551..4214593 Replicon chromosome
Accession NZ_CP096941
Organism Pseudomonas aeruginosa strain NY5523

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag M2I88_RS19595 Protein ID WP_003153636.1
Coordinates 4213551..4214126 (-) Length 192 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID I3TV68
Locus tag M2I88_RS19600 Protein ID WP_003050245.1
Coordinates 4214123..4214593 (-) Length 157 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2I88_RS19570 (M2I88_19515) 4209989..4210714 - 726 WP_003050273.1 CBASS effector endonuclease NucC -
M2I88_RS19575 (M2I88_19520) 4210753..4211655 - 903 WP_003090158.1 CBASS oligonucleotide cyclase -
M2I88_RS19580 (M2I88_19525) 4211655..4212155 - 501 WP_003090159.1 type III CBASS phage resistance system CD-NTase-associated protein Cap7 -
M2I88_RS19585 (M2I88_19530) 4212152..4212622 - 471 WP_063305693.1 type III CBASS phage resistance system CD-NTase-associated protein Cap8 -
M2I88_RS19590 (M2I88_19535) 4212619..4213533 - 915 WP_016852809.1 AAA family ATPase -
M2I88_RS19595 (M2I88_19540) 4213551..4214126 - 576 WP_003153636.1 PIN domain-containing protein Toxin
M2I88_RS19600 (M2I88_19545) 4214123..4214593 - 471 WP_003050245.1 helix-turn-helix domain-containing protein Antitoxin
M2I88_RS19605 (M2I88_19550) 4214797..4215180 + 384 WP_003090167.1 RAQPRD family integrative conjugative element protein -
M2I88_RS19610 (M2I88_19555) 4215177..4215410 + 234 WP_006226027.1 TIGR03758 family integrating conjugative element protein -
M2I88_RS19615 (M2I88_19560) 4215427..4215786 + 360 WP_003090173.1 TIGR03745 family integrating conjugative element membrane protein -
M2I88_RS19620 (M2I88_19565) 4215798..4216196 + 399 WP_003050133.1 TIGR03750 family conjugal transfer protein -
M2I88_RS19625 (M2I88_19570) 4216193..4216885 + 693 WP_003090182.1 TIGR03746 family integrating conjugative element protein -
M2I88_RS19630 (M2I88_19575) 4216882..4217793 + 912 WP_006226028.1 TIGR03749 family integrating conjugative element protein -
M2I88_RS19635 (M2I88_19580) 4217783..4219201 + 1419 WP_006226029.1 TIGR03752 family integrating conjugative element protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 4165155..4289168 124013


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-114)

Antitoxin

Helix-turn-helix domain, group 17

(85-133)


Sequences

Toxin        


Download         Length: 192 a.a.        Molecular weight: 21629.78 Da        Isoelectric Point: 5.9995

>T244220 WP_003153636.1 NZ_CP096941:c4214126-4213551 [Pseudomonas aeruginosa]
MRHSPFTAVYDACVLYPAPLRDFLMWLGLSGRFRARWSQAIHEEWKRNLLINRPDLTRVQVDRTSDLMDRAIPDGLVEGY
EALVAGLTLPDPNDRHVLAAAIRCGASVIVTFNERDFPNDLLAPYGIESQHPDEFVDNLLDLDAAAVVSAAQRQRAQLKH
PPIDVDRYLEILLRQGLVQTTKVLATYRTIL

Download         Length: 576 bp

Antitoxin


Download         Length: 157 a.a.        Molecular weight: 17245.62 Da        Isoelectric Point: 6.3803

>AT244220 WP_003050245.1 NZ_CP096941:c4214593-4214123 [Pseudomonas aeruginosa]
MTTATAQSKMTLPAAGEVKAAVQGQRALAAYLATQFETQHIQIFDDHKQAHQVELPTSALRLLVDILAELADGNAVKVVP
VHAELTTQEAADLLNVSRPHFVKLLEDGVLAFHRTGKHRRVRFADLMQYKEARERASEQAMAELAQQSQELGMGYE

Download         Length: 471 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB I3TV68

References