Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3607227..3608448 Replicon chromosome
Accession NZ_CP096937
Organism Pseudomonas aeruginosa strain NY5520

Toxin (Protein)


Gene name vapC Uniprot ID A0A0C7CS07
Locus tag M2I89_RS17060 Protein ID WP_003102740.1
Coordinates 3607870..3608448 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag M2I89_RS17055 Protein ID WP_003088112.1
Coordinates 3607227..3607781 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2I89_RS17030 (M2I89_16975) 3602795..3603346 + 552 WP_003102727.1 XRE family transcriptional regulator -
M2I89_RS17035 (M2I89_16980) 3603343..3603741 - 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
M2I89_RS17040 (M2I89_16985) 3603754..3604077 - 324 WP_003102734.1 multidrug efflux SMR transporter -
M2I89_RS17045 (M2I89_16990) 3604408..3604869 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
M2I89_RS17050 (M2I89_16995) 3604874..3607069 + 2196 WP_004349295.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
M2I89_RS17055 (M2I89_17000) 3607227..3607781 + 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
M2I89_RS17060 (M2I89_17005) 3607870..3608448 + 579 WP_003102740.1 HD domain-containing protein Toxin
M2I89_RS17065 (M2I89_17010) 3608557..3609744 - 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
M2I89_RS17070 (M2I89_17015) 3609734..3611905 - 2172 WP_009876279.1 type I secretion system permease/ATPase -
M2I89_RS17075 (M2I89_17020) 3611895..3613172 - 1278 WP_003102743.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21869.70 Da        Isoelectric Point: 5.3655

>T244213 WP_003102740.1 NZ_CP096937:3607870-3608448 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT244213 WP_003088112.1 NZ_CP096937:3607227-3607781 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C7CS07

Antitoxin

Source ID Structure

References