Detailed information of TA system TA244212

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Acetyltransf_4(toxin)
• Location: 1986735..1988243
• Replicon: chromosome
• Accession: NZ_CP096937
• Organism: Pseudomonas aeruginosa strain NY5520

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: M2I89_RS09545
• Protein ID: WP_012613851.1
• Coordinates: 1986735..1987322 (+)
• Length: 196 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: M2I89_RS09550
• Protein ID: WP_012613852.1
• Coordinates: 1987389..1988243 (+)
• Length: 285 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M2I89_RS09540 (M2I89_09525)	1982990..1986469	-	3480	WP_003117605.1	PAS domain-containing hybrid sensor histidine kinase/response regulator	-
M2I89_RS09545 (M2I89_09530)	1986735..1987322	+	588	WP_012613851.1	GNAT family protein	Toxin
M2I89_RS09550 (M2I89_09535)	1987389..1988243	+	855	WP_012613852.1	AraC family transcriptional regulator	Antitoxin
M2I89_RS09555 (M2I89_09540)	1988340..1990505	+	2166	WP_003091606.1	TonB-dependent receptor family protein	-
M2I89_RS09560 (M2I89_09545)	1990680..1992554	+	1875	WP_023128709.1	MFS transporter	-
M2I89_RS09565 (M2I89_09550)	1992615..1992824	-	210	WP_003091604.1	cold-shock protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (20-152)

Antitoxin

• AraC-type arabinose-binding/dimerisation domain (19-151)

Sequences

Toxin

Protein

• Length: 196 a.a.
• Molecular weight: 21929.29 Da
• Isoelectric Point: 9.8676

>T244212 WP_012613851.1 NZ_CP096937:1986735-1987322 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAVLEASFTG

Nucleotide

• Length: 588 bp

Antitoxin

Protein

• Length: 285 a.a.
• Molecular weight: 31959.27 Da
• Isoelectric Point: 7.3276

>AT244212 WP_012613852.1 NZ_CP096937:1987389-1988243 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHADSLETQTRWRETVLALFRRH
ARLPEAPKAGQEPLPVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTIYE

Nucleotide

• Length: 855 bp