Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3715864..3717085 Replicon chromosome
Accession NZ_CP096934
Organism Pseudomonas aeruginosa strain NY5511

Toxin (Protein)


Gene name vapC Uniprot ID A0A0C7CS07
Locus tag M2I85_RS17835 Protein ID WP_003102740.1
Coordinates 3715864..3716442 (-) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag M2I85_RS17840 Protein ID WP_003088112.1
Coordinates 3716531..3717085 (-) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2I85_RS17820 (M2I85_17800) 3711140..3712417 + 1278 WP_003102743.1 TolC family protein -
M2I85_RS17825 (M2I85_17805) 3712407..3714578 + 2172 WP_009876279.1 type I secretion system permease/ATPase -
M2I85_RS17830 (M2I85_17810) 3714568..3715755 + 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
M2I85_RS17835 (M2I85_17815) 3715864..3716442 - 579 WP_003102740.1 HD domain-containing protein Toxin
M2I85_RS17840 (M2I85_17820) 3716531..3717085 - 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
M2I85_RS17845 (M2I85_17825) 3717243..3719438 - 2196 WP_004349295.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
M2I85_RS17850 (M2I85_17830) 3719443..3719904 - 462 WP_003102736.1 (2Fe-2S)-binding protein -
M2I85_RS17855 (M2I85_17835) 3720235..3720558 + 324 WP_003102734.1 multidrug efflux SMR transporter -
M2I85_RS17860 (M2I85_17840) 3720571..3720969 + 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
M2I85_RS17865 (M2I85_17845) 3720966..3721517 - 552 WP_003102727.1 XRE family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21869.70 Da        Isoelectric Point: 5.3655

>T244209 WP_003102740.1 NZ_CP096934:c3716442-3715864 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT244209 WP_003088112.1 NZ_CP096934:c3717085-3716531 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C7CS07

Antitoxin

Source ID Structure

References