244203

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3756940..3758161 Replicon chromosome
Accession NZ_CP096932
Organism Pseudomonas aeruginosa strain NY5510

Toxin (Protein)


Gene name vapC Uniprot ID A0A0C7CS07
Locus tag M2I84_RS17820 Protein ID WP_003102740.1
Coordinates 3757583..3758161 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag M2I84_RS17815 Protein ID WP_003088112.1
Coordinates 3756940..3757494 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2I84_RS17790 (M2I84_17730) 3752508..3753059 + 552 WP_003102727.1 XRE family transcriptional regulator -
M2I84_RS17795 (M2I84_17735) 3753056..3753454 - 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
M2I84_RS17800 (M2I84_17740) 3753467..3753790 - 324 WP_003102734.1 multidrug efflux SMR transporter -
M2I84_RS17805 (M2I84_17745) 3754121..3754582 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
M2I84_RS17810 (M2I84_17750) 3754587..3756782 + 2196 WP_004349295.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
M2I84_RS17815 (M2I84_17755) 3756940..3757494 + 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
M2I84_RS17820 (M2I84_17760) 3757583..3758161 + 579 WP_003102740.1 HD domain-containing protein Toxin
M2I84_RS17825 (M2I84_17765) 3758270..3759457 - 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
M2I84_RS17830 (M2I84_17770) 3759447..3761618 - 2172 WP_009876279.1 type I secretion system permease/ATPase -
M2I84_RS17835 (M2I84_17775) 3761608..3762885 - 1278 WP_003102743.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21869.70 Da        Isoelectric Point: 5.3655

>T244203 WP_003102740.1 NZ_CP096932:3757583-3758161 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT244203 WP_003088112.1 NZ_CP096932:3756940-3757494 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C7CS07

Antitoxin

Source ID Structure

References