Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3904570..3905791 Replicon chromosome
Accession NZ_CP096929
Organism Pseudomonas aeruginosa strain NY5507

Toxin (Protein)


Gene name vapC Uniprot ID A0A0C7CS07
Locus tag M2I83_RS18365 Protein ID WP_003102740.1
Coordinates 3905213..3905791 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag M2I83_RS18360 Protein ID WP_003088112.1
Coordinates 3904570..3905124 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2I83_RS18335 (M2I83_18295) 3900138..3900689 + 552 WP_003102727.1 XRE family transcriptional regulator -
M2I83_RS18340 (M2I83_18300) 3900686..3901084 - 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
M2I83_RS18345 (M2I83_18305) 3901097..3901420 - 324 WP_003102734.1 multidrug efflux SMR transporter -
M2I83_RS18350 (M2I83_18310) 3901751..3902212 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
M2I83_RS18355 (M2I83_18315) 3902217..3904412 + 2196 WP_004349295.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
M2I83_RS18360 (M2I83_18320) 3904570..3905124 + 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
M2I83_RS18365 (M2I83_18325) 3905213..3905791 + 579 WP_003102740.1 HD domain-containing protein Toxin
M2I83_RS18370 (M2I83_18330) 3905900..3907087 - 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
M2I83_RS18375 (M2I83_18335) 3907077..3909248 - 2172 WP_009876279.1 type I secretion system permease/ATPase -
M2I83_RS18380 (M2I83_18340) 3909238..3910515 - 1278 WP_003102743.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21869.70 Da        Isoelectric Point: 5.3655

>T244198 WP_003102740.1 NZ_CP096929:3905213-3905791 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT244198 WP_003088112.1 NZ_CP096929:3904570-3905124 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C7CS07

Antitoxin

Source ID Structure

References