Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | slvAT/RES(toxin) |
| Location | 147859..148775 | Replicon | plasmid pNY5506-SIM |
| Accession | NZ_CP096928 | ||
| Organism | Pseudomonas aeruginosa strain NY5506 | ||
Toxin (Protein)
| Gene name | slvT | Uniprot ID | A0A2L1KI32 |
| Locus tag | M2I82_RS30035 | Protein ID | WP_019437783.1 |
| Coordinates | 147859..148383 (-) | Length | 175 a.a. |
Antitoxin (Protein)
| Gene name | slvA | Uniprot ID | A0A2L1KH13 |
| Locus tag | M2I82_RS30040 | Protein ID | WP_019437782.1 |
| Coordinates | 148380..148775 (-) | Length | 132 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| M2I82_RS30015 (M2I82_29950) | 143180..144325 | + | 1146 | WP_021263240.1 | glycerate kinase | - |
| M2I82_RS30020 (M2I82_29955) | 144745..144936 | - | 192 | WP_019437785.1 | hypothetical protein | - |
| M2I82_RS30025 (M2I82_29960) | 145311..146366 | + | 1056 | WP_139139567.1 | prepilin-type N-terminal cleavage/methylation domain-containing protein | - |
| M2I82_RS30030 (M2I82_29965) | 146563..147813 | + | 1251 | WP_019437784.1 | TerD family protein | - |
| M2I82_RS30035 (M2I82_29970) | 147859..148383 | - | 525 | WP_019437783.1 | RES family NAD+ phosphorylase | Toxin |
| M2I82_RS30040 (M2I82_29975) | 148380..148775 | - | 396 | WP_019437782.1 | hypothetical protein | Antitoxin |
| M2I82_RS30045 (M2I82_29980) | 149359..151242 | - | 1884 | WP_223819158.1 | helicase | - |
| M2I82_RS30050 (M2I82_29985) | 151442..151696 | + | 255 | WP_021263738.1 | hypothetical protein | - |
| M2I82_RS30055 (M2I82_29990) | 152602..153126 | + | 525 | WP_166729438.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | aac(6')-IIa / qnrVC1 / blaVIM-2 / aph(3')-Ia / mph(E) / msr(E) / sul1 / qacE / catB3 / ere(A) / blaSIM-1 | - | 1..416743 | 416743 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 175 a.a. Molecular weight: 19052.57 Da Isoelectric Point: 4.5535
>T244195 WP_019437783.1 NZ_CP096928:c148383-147859 [Pseudomonas aeruginosa]
MKIIGVQDLPCYRMHTPKWSVAPTSGAGAATQGGRVNRKGLEALYLSLESATAIAEFQQASAFLPPGLLISYSLSLDRVI
DFTGGYNDTWAPIWQDFFCDWRKIRFNDGVEPPSWIIGDLAIEADCAGILFESVANPGGRNLVLFTDQLPVHGNIVVNDP
RGDLPTDQSSWTRP
MKIIGVQDLPCYRMHTPKWSVAPTSGAGAATQGGRVNRKGLEALYLSLESATAIAEFQQASAFLPPGLLISYSLSLDRVI
DFTGGYNDTWAPIWQDFFCDWRKIRFNDGVEPPSWIIGDLAIEADCAGILFESVANPGGRNLVLFTDQLPVHGNIVVNDP
RGDLPTDQSSWTRP
Download Length: 525 bp
Antitoxin
Download Length: 132 a.a. Molecular weight: 14753.87 Da Isoelectric Point: 7.2048
>AT244195 WP_019437782.1 NZ_CP096928:c148775-148380 [Pseudomonas aeruginosa]
MASKAVLELRPTNFAGLMDALKEVNRVMFSPERFLKVFSMDQQTLALRAHVHRNTVRNAPESEKVQAYIRDSVKVLRAVT
DMGTDVTNAIFWFKNEPLSTFGYKTAEEVVSEGKTEQLIAFLQSWEAGAQG
MASKAVLELRPTNFAGLMDALKEVNRVMFSPERFLKVFSMDQQTLALRAHVHRNTVRNAPESEKVQAYIRDSVKVLRAVT
DMGTDVTNAIFWFKNEPLSTFGYKTAEEVVSEGKTEQLIAFLQSWEAGAQG
Download Length: 396 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2L1KI32 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2L1KH13 |