Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 5096057..5096643 Replicon chromosome
Accession NZ_CP096927
Organism Pseudomonas aeruginosa strain NY5506

Toxin (Protein)


Gene name PumA Uniprot ID G8CP73
Locus tag M2I82_RS23575 Protein ID WP_003120987.1
Coordinates 5096344..5096643 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag M2I82_RS23570 Protein ID WP_003448662.1
Coordinates 5096057..5096347 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2I82_RS23550 (M2I82_23495) 5091633..5093528 + 1896 WP_234493604.1 hypothetical protein -
M2I82_RS23555 (M2I82_23500) 5093525..5095501 + 1977 WP_270018599.1 DEAD/DEAH box helicase -
M2I82_RS23560 5095511..5095645 + 135 WP_033179080.1 hypothetical protein -
M2I82_RS23565 (M2I82_23505) 5095642..5095986 + 345 WP_003448665.1 hypothetical protein -
M2I82_RS23570 (M2I82_23510) 5096057..5096347 - 291 WP_003448662.1 putative addiction module antidote protein Antitoxin
M2I82_RS23575 (M2I82_23515) 5096344..5096643 - 300 WP_003120987.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M2I82_RS23580 (M2I82_23520) 5096845..5097966 + 1122 WP_003448658.1 TcpQ domain-containing protein -
M2I82_RS23585 (M2I82_23525) 5097966..5099675 + 1710 WP_010792227.1 PilN family type IVB pilus formation outer membrane protein -
M2I82_RS23590 (M2I82_23530) 5099679..5101004 + 1326 WP_003099758.1 type 4b pilus protein PilO2 -
M2I82_RS23595 (M2I82_23535) 5100994..5101527 + 534 WP_003099760.1 type IV pilus biogenesis protein PilP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 5067718..5153598 85880


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-96)

Antitoxin

Cro/C1-type helix-turn-helix domain

(47-90)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11133.88 Da        Isoelectric Point: 10.4495

>T244193 WP_003120987.1 NZ_CP096927:c5096643-5096344 [Pseudomonas aeruginosa]
MVEVKQTATFMAWESKLKDRRAKAVIAARIFRLANGLPGDVSPVGQGVSELRIHYGPGYRVYFQQRGTEIVILLCGGDKS
SQARDIEMAKRLANEWRPQ

Download         Length: 300 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10394.91 Da        Isoelectric Point: 4.7527

>AT244193 WP_003448662.1 NZ_CP096927:c5096347-5096057 [Pseudomonas aeruginosa]
MTEQIYDYDPAQALDSPEAMALFIADALDTGDTAYIAKAMGVVARAKGMTELAKETGLAREQLYKSFSERGNPTLKTMLA
VMRALGVDLTARPHAQ

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G8CP73

Antitoxin

Source ID Structure

References