Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 4429115..4430373 Replicon chromosome
Accession NZ_CP096927
Organism Pseudomonas aeruginosa strain NY5506

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag M2I82_RS20390 Protein ID WP_012614407.1
Coordinates 4429115..4429870 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag M2I82_RS20395 Protein ID WP_003086329.1
Coordinates 4430005..4430373 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2I82_RS20380 (M2I82_20325) 4424288..4426831 + 2544 WP_019682207.1 acyl-homoserine-lactone acylase QuiP -
M2I82_RS20385 (M2I82_20330) 4426986..4428347 - 1362 WP_073666947.1 DNA recombination protein RmuC -
M2I82_RS20390 (M2I82_20335) 4429115..4429870 - 756 WP_012614407.1 RES family NAD+ phosphorylase Toxin
M2I82_RS20395 (M2I82_20340) 4430005..4430373 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
M2I82_RS20400 (M2I82_20345) 4430446..4431732 - 1287 WP_012614408.1 FAD-binding oxidoreductase -
M2I82_RS20405 (M2I82_20350) 4431788..4433281 - 1494 WP_003086325.1 aldehyde dehydrogenase family protein -
M2I82_RS20410 (M2I82_20355) 4433456..4433932 + 477 WP_003112531.1 hypothetical protein -
M2I82_RS20415 (M2I82_20360) 4433935..4434210 - 276 WP_169057979.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28250.37 Da        Isoelectric Point: 7.7294

>T244192 WP_012614407.1 NZ_CP096927:c4429870-4429115 [Pseudomonas aeruginosa]
VSEIWRQCKGERHVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGTAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT244192 WP_003086329.1 NZ_CP096927:c4430373-4430005 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References