Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 2419129..2419645 Replicon chromosome
Accession NZ_CP096927
Organism Pseudomonas aeruginosa strain NY5506

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag M2I82_RS11480 Protein ID WP_224154839.1
Coordinates 2419364..2419645 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A3R8UIM7
Locus tag M2I82_RS11475 Protein ID WP_025297454.1
Coordinates 2419129..2419374 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2I82_RS11455 (M2I82_11435) 2414248..2414580 - 333 WP_071536798.1 hypothetical protein -
M2I82_RS11460 (M2I82_11440) 2414928..2415596 + 669 WP_071536799.1 hypothetical protein -
M2I82_RS11465 (M2I82_11445) 2415593..2416699 + 1107 WP_043106099.1 XRE family transcriptional regulator -
M2I82_RS11470 (M2I82_11450) 2416842..2418971 + 2130 WP_224154841.1 NERD domain-containing protein -
M2I82_RS11475 (M2I82_11455) 2419129..2419374 + 246 WP_025297454.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
M2I82_RS11480 (M2I82_11460) 2419364..2419645 + 282 WP_224154839.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M2I82_RS11485 (M2I82_11465) 2420054..2420635 - 582 WP_224154837.1 plasmid pRiA4b ORF-3 family protein -
M2I82_RS11490 (M2I82_11470) 2420649..2421524 - 876 WP_043107117.1 WYL domain-containing protein -
M2I82_RS11495 (M2I82_11475) 2421653..2423233 + 1581 WP_063837559.1 DNA recombination protein RmuC -
M2I82_RS11500 (M2I82_11480) 2423257..2423904 + 648 WP_043106453.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(10-71)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10834.65 Da        Isoelectric Point: 10.6249

>T244190 WP_224154839.1 NZ_CP096927:2419364-2419645 [Pseudomonas aeruginosa]
MTYELELLPSALKEWQKLGHTVREQIKKKLRERLDNPKVQADALRDMPGHYKIKLRTSGYRLVYRVEDERLVVVVVAVGK
RERGAAYQSAKGR

Download         Length: 282 bp

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8797.21 Da        Isoelectric Point: 4.2550

>AT244190 WP_025297454.1 NZ_CP096927:2419129-2419374 [Pseudomonas aeruginosa]
MQSILADVAVSVSELKKNPSGILAGAGGMPVAVLNHNRVMGYMVPAELYEQMMERLDDLELVEIVKARSGEESVPVRLDD
L

Download         Length: 246 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A3R8UIM7

References