Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 145613..146118 Replicon chromosome
Accession NZ_CP096927
Organism Pseudomonas aeruginosa strain NY5506

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag M2I82_RS00680 Protein ID WP_003083773.1
Coordinates 145613..145894 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q9I707
Locus tag M2I82_RS00685 Protein ID WP_003112628.1
Coordinates 145891..146118 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2I82_RS00655 (M2I82_00655) 140864..142213 + 1350 WP_003142411.1 C4-dicarboxylate transporter DctA -
M2I82_RS00660 (M2I82_00660) 142262..142948 + 687 WP_004351997.1 FadR/GntR family transcriptional regulator -
M2I82_RS00665 (M2I82_00665) 143049..143783 + 735 WP_003117208.1 GntR family transcriptional regulator -
M2I82_RS00670 (M2I82_00670) 143963..144373 + 411 WP_003101225.1 aegerolysin family protein -
M2I82_RS00675 (M2I82_00675) 144405..145313 - 909 WP_003083769.1 LysR family transcriptional regulator -
M2I82_RS00680 (M2I82_00680) 145613..145894 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
M2I82_RS00685 (M2I82_00685) 145891..146118 - 228 WP_003112628.1 CopG family ribbon-helix-helix protein Antitoxin
M2I82_RS00690 (M2I82_00690) 146293..146913 - 621 WP_009314940.1 hypothetical protein -
M2I82_RS00695 (M2I82_00695) 147021..147521 + 501 WP_003112629.1 LEA type 2 family protein -
M2I82_RS00700 (M2I82_00700) 147594..147935 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
M2I82_RS00705 (M2I82_00705) 148017..149444 - 1428 WP_003083784.1 GABA permease -
M2I82_RS00710 (M2I82_00710) 149613..151106 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T244188 WP_003083773.1 NZ_CP096927:c145894-145613 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8568.64 Da        Isoelectric Point: 5.5740

>AT244188 WP_003112628.1 NZ_CP096927:c146118-145891 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHIEIEKRWGLQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
PDB 6XRW
AlphaFold DB Q9I707

References