Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3496146..3496767 Replicon chromosome
Accession NZ_CP096923
Organism Enterobacter hormaechei strain NY0401

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag M2M22_RS16670 Protein ID WP_015571250.1
Coordinates 3496146..3496364 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag M2M22_RS16675 Protein ID WP_006809850.1
Coordinates 3496393..3496767 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2M22_RS16640 (M2M22_16635) 3492158..3492418 + 261 WP_015571255.1 type B 50S ribosomal protein L31 -
M2M22_RS16645 (M2M22_16640) 3492421..3492561 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
M2M22_RS16650 (M2M22_16645) 3492558..3493268 - 711 WP_063146586.1 GNAT family protein -
M2M22_RS16655 (M2M22_16650) 3493371..3494831 + 1461 WP_063146585.1 PLP-dependent aminotransferase family protein -
M2M22_RS16660 (M2M22_16655) 3494803..3495270 - 468 WP_022647269.1 YlaC family protein -
M2M22_RS16665 (M2M22_16660) 3495387..3495938 - 552 WP_063146584.1 maltose O-acetyltransferase -
M2M22_RS16670 (M2M22_16665) 3496146..3496364 - 219 WP_015571250.1 HHA domain-containing protein Toxin
M2M22_RS16675 (M2M22_16670) 3496393..3496767 - 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
M2M22_RS16680 (M2M22_16675) 3497277..3500423 - 3147 WP_023299464.1 multidrug efflux RND transporter permease subunit AcrB -
M2M22_RS16685 (M2M22_16680) 3500446..3501639 - 1194 WP_022647272.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T244187 WP_015571250.1 NZ_CP096923:c3496364-3496146 [Enterobacter hormaechei]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT244187 WP_006809850.1 NZ_CP096923:c3496767-3496393 [Enterobacter hormaechei]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References