Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 2340124..2340740 Replicon chromosome
Accession NZ_CP096923
Organism Enterobacter hormaechei strain NY0401

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag M2M22_RS11150 Protein ID WP_080469998.1
Coordinates 2340124..2340495 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A9E7BIL4
Locus tag M2M22_RS11155 Protein ID WP_023298920.1
Coordinates 2340498..2340740 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2M22_RS11135 (M2M22_11130) 2337624..2338526 + 903 WP_003861960.1 formate dehydrogenase subunit beta -
M2M22_RS11140 (M2M22_11135) 2338523..2339158 + 636 WP_006808711.1 formate dehydrogenase cytochrome b556 subunit -
M2M22_RS11145 (M2M22_11140) 2339155..2340084 + 930 WP_022649835.1 formate dehydrogenase accessory protein FdhE -
M2M22_RS11150 (M2M22_11145) 2340124..2340495 - 372 WP_080469998.1 type II toxin-antitoxin system VapC family toxin Toxin
M2M22_RS11155 (M2M22_11150) 2340498..2340740 - 243 WP_023298920.1 ribbon-helix-helix protein, CopG family Antitoxin
M2M22_RS11160 (M2M22_11155) 2340940..2341860 + 921 WP_063146850.1 alpha/beta hydrolase -
M2M22_RS11165 (M2M22_11160) 2341869..2342810 - 942 WP_022649838.1 fatty acid biosynthesis protein FabY -
M2M22_RS11170 (M2M22_11165) 2342855..2343292 - 438 WP_063146849.1 D-aminoacyl-tRNA deacylase -
M2M22_RS11175 (M2M22_11170) 2343289..2344170 - 882 WP_023298923.1 virulence factor BrkB family protein -
M2M22_RS11180 (M2M22_11175) 2344164..2344763 - 600 WP_003861947.1 glucose-1-phosphatase -
M2M22_RS11185 (M2M22_11180) 2344882..2345682 - 801 WP_023298924.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2330347..2341860 11513


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-114)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-49)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13624.68 Da        Isoelectric Point: 6.4866

>T244186 WP_080469998.1 NZ_CP096923:c2340495-2340124 [Enterobacter hormaechei]
MEHMAVFDTNILIDLFNNHVEAADAIDRTASHRAISLITWMEVMVGARRHGQEARTAAVMGAFEIIDITREIAERSVLLR
EQHGMKLPDAIILATAQSRSCPLISRNTKDFSGIAGVVSPYHL

Download         Length: 372 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9467.74 Da        Isoelectric Point: 4.3775

>AT244186 WP_023298920.1 NZ_CP096923:c2340740-2340498 [Enterobacter hormaechei]
MSLLADLTMGRILIDLSDDVIQRLDNLKQLRNRPRAELLREAIELYLDQQNSSVIREALGLWGNQQEDGLEYERKLREEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References