Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2217977..2218584 Replicon chromosome
Accession NZ_CP096923
Organism Enterobacter hormaechei strain NY0401

Toxin (Protein)


Gene name hicA Uniprot ID A0A2J0PXG2
Locus tag M2M22_RS10600 Protein ID WP_071788668.1
Coordinates 2218399..2218584 (-) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag M2M22_RS10595 Protein ID WP_063147030.1
Coordinates 2217977..2218384 (-) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2M22_RS10565 (M2M22_10560) 2213818..2214471 + 654 WP_023298862.1 3-keto-L-gulonate-6-phosphate decarboxylase UlaD -
M2M22_RS10570 (M2M22_10565) 2214474..2215334 + 861 WP_023298863.1 L-ribulose-5-phosphate 3-epimerase -
M2M22_RS10575 (M2M22_10570) 2215328..2216023 + 696 WP_038416909.1 L-ribulose-5-phosphate 4-epimerase -
M2M22_RS10580 (M2M22_10575) 2216024..2216314 - 291 Protein_2074 helix-turn-helix domain-containing protein -
M2M22_RS10585 (M2M22_10580) 2216309..2216695 + 387 Protein_2075 glycoside hydrolase family 127 protein -
M2M22_RS10590 (M2M22_10585) 2216897..2217973 + 1077 WP_047354172.1 type I restriction enzyme HsdR N-terminal domain-containing protein -
M2M22_RS10595 (M2M22_10590) 2217977..2218384 - 408 WP_063147030.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
M2M22_RS10600 (M2M22_10595) 2218399..2218584 - 186 WP_071788668.1 type II toxin-antitoxin system HicA family toxin Toxin
M2M22_RS10605 (M2M22_10600) 2218828..2220366 - 1539 WP_023307168.1 aldehyde dehydrogenase AldB -
M2M22_RS10610 (M2M22_10605) 2220533..2221417 + 885 WP_270094182.1 ROK family protein -
M2M22_RS10615 (M2M22_10610) 2221421..2223259 - 1839 WP_063842094.1 selenocysteine-specific translation elongation factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6822.05 Da        Isoelectric Point: 11.5191

>T244185 WP_071788668.1 NZ_CP096923:c2218584-2218399 [Enterobacter hormaechei]
VKSADIIAVLVSHGWKCVRTKGSHHQFRHPVQKGLVTVPHPKKDIKPGTLAQIWRQAGIKH

Download         Length: 186 bp

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 15146.93 Da        Isoelectric Point: 4.4217

>AT244185 WP_063147030.1 NZ_CP096923:c2218384-2217977 [Enterobacter hormaechei]
MFYPAYIHSDSDGSASGFFPDVPGCFFAGDSLDDAFQDAREALTAHFEALFEMDEALPLPGNVEVHLENHPDDFSGGQWL
LVDINMKQFDGRAERINITMPRRLLVKIDSFVSEHPQFGNRSAFLAEAARRVLPR

Download         Length: 408 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J0PXG2

Antitoxin

Source ID Structure

References