Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1528132..1528789 Replicon chromosome
Accession NZ_CP096923
Organism Enterobacter hormaechei strain NY0401

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag M2M22_RS07285 Protein ID WP_063146504.1
Coordinates 1528132..1528542 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag M2M22_RS07290 Protein ID WP_003863437.1
Coordinates 1528523..1528789 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2M22_RS07265 (M2M22_07260) 1524130..1525863 - 1734 WP_063146503.1 single-stranded-DNA-specific exonuclease RecJ -
M2M22_RS07270 (M2M22_07265) 1525869..1526582 - 714 WP_022649304.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
M2M22_RS07275 (M2M22_07270) 1526611..1527507 - 897 WP_003863442.1 site-specific tyrosine recombinase XerD -
M2M22_RS07280 (M2M22_07275) 1527609..1528130 + 522 WP_015571793.1 flavodoxin FldB -
M2M22_RS07285 (M2M22_07280) 1528132..1528542 - 411 WP_063146504.1 protein YgfX Toxin
M2M22_RS07290 (M2M22_07285) 1528523..1528789 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
M2M22_RS07295 (M2M22_07290) 1529084..1530064 + 981 WP_063146505.1 tRNA-modifying protein YgfZ -
M2M22_RS07300 (M2M22_07295) 1530586..1531245 - 660 WP_022649307.1 hemolysin III family protein -
M2M22_RS07305 (M2M22_07300) 1531512..1532243 + 732 WP_063146842.1 MurR/RpiR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16312.19 Da        Isoelectric Point: 11.4775

>T244184 WP_063146504.1 NZ_CP096923:c1528542-1528132 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAAMVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMIGTPWMLNTGMMLRLRRVEDNRRQQLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT244184 WP_003863437.1 NZ_CP096923:c1528789-1528523 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References