Detailed information of TA system TA024417

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /HTH_XRE(antitoxin)
• Location: 2082567..2083364
• Replicon: chromosome
• Accession: NC_013450
• Organism: Staphylococcus aureus subsp. aureus ED98

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: SAAV_RS10635
• Protein ID: WP_000525014.1
• Coordinates: 2082903..2083364 (+)
• Length: 154 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: A0A0C2LD36
• Locus tag: SAAV_RS10630
• Protein ID: WP_001260487.1
• Coordinates: 2082567..2082890 (+)
• Length: 108 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SAAV_RS10565	2077626..2078384	-	759	WP_001003951.1	DUF1351 domain-containing protein	-
SAAV_RS10570	2078395..2078718	-	324	WP_000171560.1	hypothetical protein	-
SAAV_RS10575	2078731..2079342	-	612	WP_001105358.1	MBL fold metallo-hydrolase	-
SAAV_RS10580	2079365..2079601	-	237	WP_000802314.1	hypothetical protein	-
SAAV_RS10585	2079609..2079869	-	261	WP_000291082.1	DUF1108 family protein	-
SAAV_RS10590	2079968..2080129	-	162	WP_001285953.1	DUF1270 family protein	-
SAAV_RS10595	2080126..2080446	-	321	WP_001120202.1	DUF771 domain-containing protein	-
SAAV_RS10600	2080597..2080740	-	144	WP_000939498.1	hypothetical protein	-
SAAV_RS15420	2080807..2081029	+	223	Protein_2005	hypothetical protein	-
SAAV_RS10615	2081282..2081494	+	213	WP_000362645.1	hypothetical protein	-
SAAV_RS15425	2081535..2081684	-	150	WP_000771849.1	hypothetical protein	-
SAAV_RS10620	2081699..2082142	-	444	WP_000435352.1	hypothetical protein	-
SAAV_RS10625	2082155..2082403	-	249	WP_000272856.1	helix-turn-helix domain-containing protein	-
SAAV_RS10630	2082567..2082890	+	324	WP_001260487.1	helix-turn-helix domain-containing protein	Antitoxin
SAAV_RS10635	2082903..2083364	+	462	WP_000525014.1	hypothetical protein	Toxin
SAAV_RS15320	2083381..2083602	+	222	Protein_2012	membrane lipoprotein lipid attachment site-containing protein	-
SAAV_RS10645	2083896..2084780	+	885	WP_001025527.1	hypothetical protein	-
SAAV_RS10655	2085086..2085454	+	369	Protein_2014	hypothetical protein	-
SAAV_RS15430	2085553..2085720	+	168	WP_001166555.1	hypothetical protein	-
SAAV_RS14990	2086060..2086764	+	705	Protein_2016	type II toxin-antitoxin system PemK/MazF family toxin	-
SAAV_RS10665	2086926..2087963	+	1038	WP_000857172.1	site-specific integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	hlb / groEL	2044774..2097043	52269

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (8-65)

Sequences

Toxin

Protein

• Length: 154 a.a.
• Molecular weight: 18104.44 Da
• Isoelectric Point: 4.6915

>T24417 WP_000525014.1 NC_013450:2082903-2083364 [Staphylococcus aureus subsp. aureus ED98]
MGLYEETLIQHDYIEVREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVYRYKEI

Nucleotide

• Length: 462 bp

>T24417 NC_013450:2082903-2083364 [Staphylococcus aureus subsp. aureus ED98]
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAGTAAGAGAGGCTGATGTACTTCCAGATAATTTAGA
CGGGGTATGGTTAGGAGATTTAATTTTAATAAAGCGTGGTTTATCAGATAGAGAAAAGGCAGGAATTCTCTTCGAAGAAT
TAGCACATAATAAACTTACATACGGTGATATAGCCGATTACTCGAAATTCAACAATCGCAAGTTCGAAAATTACGCAAGA
CGACACGGCTTTATCTCAGCTGTACCGCTACGCGAAATTGTAGAAGCTTATAATTATGGCGTACGTAACTTGTATGAGTT
GTCTGAGTATCTACAATTAAGCGAAGAATACATATTAGAAGCAATAGAACAATATAAAAAGATATATGGTATTGGAACTC
ACTATGGCGAGTATTCTATTACATTTGAACCGTTGAGAGTTTATCGATACAAAGAGATATAA

Antitoxin

Protein

• Length: 108 a.a.
• Molecular weight: 12431.09 Da
• Isoelectric Point: 9.3811

>AT24417 WP_001260487.1 NC_013450:2082567-2082890 [Staphylococcus aureus subsp. aureus ED98]
MRTSAEIGKLIKQLRKENNVNLTDFATKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQTENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK

Nucleotide

• Length: 324 bp

>AT24417 NC_013450:2082567-2082890 [Staphylococcus aureus subsp. aureus ED98]
ATGAGAACTTCAGCAGAAATAGGTAAATTAATCAAACAACTACGAAAAGAGAATAATGTGAATTTAACTGATTTTGCAAC
TAAGATAGGTGTCAATAAATCTACCTTATCCCGATATGAAAACGGTAGCAGAAAAATACCTATGGAGGATATAGCTGAAA
TTGCCAATGCATTGAAAGTTACCCCAGAATATTTACTATTAAAAAATAGACAAACAGAAAACGAAGTACAACATCGAGCA
GCTCACCTTGAAGGAGAATTGACAGATGATGAATGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGTAAACGTAA
GTAA

Structures

Antitoxin

• AlphaFold DB: A0A0C2LD36