Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 2375338..2375891 Replicon chromosome
Accession NZ_CP096916
Organism Alcaligenes faecalis strain NY11312

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag M2J83_RS11155 Protein ID WP_086060439.1
Coordinates 2375338..2375664 (-) Length 109 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag M2J83_RS11160 Protein ID WP_270115614.1
Coordinates 2375661..2375891 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2J83_RS11135 (M2J83_11115) 2371402..2372793 + 1392 WP_222668021.1 integrating conjugative element protein -
M2J83_RS11140 (M2J83_11120) 2372790..2373191 + 402 WP_222668020.1 hypothetical protein -
M2J83_RS11145 (M2J83_11125) 2373206..2374831 + 1626 WP_222668019.1 conjugal transfer protein TraG N-terminal domain-containing protein -
M2J83_RS11150 (M2J83_11130) 2374835..2375086 - 252 WP_222668018.1 hypothetical protein -
M2J83_RS11155 (M2J83_11135) 2375338..2375664 - 327 WP_086060439.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
M2J83_RS11160 (M2J83_11140) 2375661..2375891 - 231 WP_270115614.1 antitoxin MazE family protein Antitoxin
M2J83_RS11165 (M2J83_11145) 2376042..2376413 - 372 WP_222668017.1 hypothetical protein -
M2J83_RS11170 (M2J83_11150) 2376595..2378022 - 1428 WP_086060051.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-103)

Antitoxin

Antitoxin MazE-like

(10-74)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 11567.56 Da        Isoelectric Point: 10.0902

>T244168 WP_086060439.1 NZ_CP096916:c2375664-2375338 [Alcaligenes faecalis]
MRRGDLVTVAMQGDFGKPRPALVIQADLFAAHSSVTVLPVTSTIVNAPLLRISIQPDLENGLQKPSQIMIDKALTVKRDK
IGQAFGSVSADTLVEIERSLAVFLGIAK

Download         Length: 327 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8760.91 Da        Isoelectric Point: 6.4607

>AT244168 WP_270115614.1 NZ_CP096916:c2375891-2375661 [Alcaligenes faecalis]
MEIKMANVNARVQKHRDSLRQAGLRPVQLWVPDTRRPDFAAECRRQALRVAKADKADVDTEHFMDEALADLDGWTE

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References