244164

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 121667..122360 Replicon plasmid pNY7610-IMP
Accession NZ_CP096914
Organism Pseudomonas aeruginosa strain NY7610

Toxin (Protein)


Gene name tad Uniprot ID N2IHR9
Locus tag M2J79_RS34100 Protein ID WP_003151133.1
Coordinates 121667..122044 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID N2IIN5
Locus tag M2J79_RS34105 Protein ID WP_001172026.1
Coordinates 122025..122360 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2J79_RS34080 (M2J79_34030) 117524..118141 + 618 WP_049277571.1 recombinase family protein -
M2J79_RS34085 (M2J79_34035) 118056..118334 - 279 Protein_118 RimK/LysX family protein -
M2J79_RS34090 (M2J79_34040) 118482..119726 - 1245 WP_049277576.1 HD-GYP domain-containing protein -
M2J79_RS34095 (M2J79_34045) 119801..121123 - 1323 WP_049277574.1 PAS domain-containing methyl-accepting chemotaxis protein -
M2J79_RS34100 (M2J79_34050) 121667..122044 + 378 WP_003151133.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M2J79_RS34105 (M2J79_34055) 122025..122360 + 336 WP_001172026.1 helix-turn-helix transcriptional regulator Antitoxin
M2J79_RS34110 (M2J79_34060) 122375..122710 + 336 WP_000741275.1 hypothetical protein -
M2J79_RS34115 (M2J79_34065) 122734..123060 + 327 WP_000091614.1 hypothetical protein -
M2J79_RS34120 (M2J79_34070) 123057..123428 + 372 WP_023103794.1 hypothetical protein -
M2J79_RS34125 (M2J79_34075) 123786..124040 - 255 WP_121757888.1 hypothetical protein -
M2J79_RS34130 (M2J79_34080) 124116..124310 - 195 WP_121757889.1 hypothetical protein -
M2J79_RS34135 (M2J79_34085) 124770..125027 + 258 WP_121757891.1 hypothetical protein -
M2J79_RS34140 (M2J79_34090) 125039..125278 + 240 WP_121757892.1 hypothetical protein -
M2J79_RS34145 (M2J79_34095) 125275..125664 - 390 WP_121757893.1 hypothetical protein -
M2J79_RS34150 (M2J79_34100) 125712..126623 - 912 WP_208722306.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaIMP-1 / aac(3)-IId / aph(6)-Id / aph(3'')-Ib - 1..152682 152682


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(40-93)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13705.78 Da        Isoelectric Point: 9.4693

>T244164 WP_003151133.1 NZ_CP096914:121667-122044 [Pseudomonas aeruginosa]
MTNKEKPLEWIASSHKDLMALPSDVRRRFGYALSLAQIGDQDDAAKVLKGFGGAGVLEVVEDDAGGTYRAVYTVKFAEAV
FVLHCFQKKSKSGIATPKADMDIIRARLKVAEVLAQELRNAKTNH

Download         Length: 378 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12201.39 Da        Isoelectric Point: 10.6058

>AT244164 WP_001172026.1 NZ_CP096914:122025-122360 [Pseudomonas aeruginosa]
MQKRIIEGVEVQRSSGNVFADLGLPDAEKLKIKTGLVVEIRRAMRALGLTQQAAAKRMGIPQPKVSGMMRGDFTNLSERK
LMDCLNRLGYDIEIKVRPAAEPIGHLTLATA

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A024ELN5

Antitoxin

Source ID Structure
AlphaFold DB A0A024EKI7

References