Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /Xre(antitoxin) |
| Location | 4802985..4804243 | Replicon | chromosome |
| Accession | NZ_CP096913 | ||
| Organism | Pseudomonas aeruginosa strain NY7610 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | A0A0H2Z7F3 |
| Locus tag | M2J79_RS22555 | Protein ID | WP_003140635.1 |
| Coordinates | 4802985..4803740 (-) | Length | 252 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | V6AJU7 |
| Locus tag | M2J79_RS22560 | Protein ID | WP_003086329.1 |
| Coordinates | 4803875..4804243 (-) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| M2J79_RS22545 (M2J79_22525) | 4798156..4800699 | + | 2544 | WP_003140632.1 | acyl-homoserine-lactone acylase QuiP | - |
| M2J79_RS22550 (M2J79_22530) | 4800854..4802215 | - | 1362 | WP_003081943.1 | DNA recombination protein RmuC | - |
| M2J79_RS22555 (M2J79_22535) | 4802985..4803740 | - | 756 | WP_003140635.1 | RES family NAD+ phosphorylase | Toxin |
| M2J79_RS22560 (M2J79_22540) | 4803875..4804243 | - | 369 | WP_003086329.1 | DUF2384 domain-containing protein | Antitoxin |
| M2J79_RS22565 (M2J79_22545) | 4804316..4805602 | - | 1287 | WP_003086327.1 | FAD-binding oxidoreductase | - |
| M2J79_RS22570 (M2J79_22550) | 4805658..4807247 | - | 1590 | WP_003140637.1 | aldehyde dehydrogenase family protein | - |
| M2J79_RS22575 (M2J79_22555) | 4807326..4807802 | + | 477 | WP_003140638.1 | hypothetical protein | - |
| M2J79_RS22580 (M2J79_22560) | 4807805..4808080 | - | 276 | WP_023098713.1 | zinc ribbon domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 252 a.a. Molecular weight: 28220.34 Da Isoelectric Point: 7.7294
>T244161 WP_003140635.1 NZ_CP096913:c4803740-4802985 [Pseudomonas aeruginosa]
VSEIWRQCKGERHVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGAPKIFSWEL
FLVDGKLPHPA
VSEIWRQCKGERHVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGAPKIFSWEL
FLVDGKLPHPA
Download Length: 756 bp
Antitoxin
Download Length: 123 a.a. Molecular weight: 13367.63 Da Isoelectric Point: 9.9874
>AT244161 WP_003086329.1 NZ_CP096913:c4804243-4803875 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV
Download Length: 369 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0H2Z7F3 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | V6AJU7 |