Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/- |
Location | 3823797..3825017 | Replicon | chromosome |
Accession | NZ_CP096913 | ||
Organism | Pseudomonas aeruginosa strain NY7610 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | A0A0H2Z8V4 |
Locus tag | M2J79_RS17875 | Protein ID | WP_003110488.1 |
Coordinates | 3824439..3825017 (+) | Length | 193 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | - |
Locus tag | M2J79_RS17870 | Protein ID | WP_003088112.1 |
Coordinates | 3823797..3824351 (+) | Length | 185 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
M2J79_RS17845 (M2J79_17835) | 3819365..3819916 | + | 552 | WP_003139878.1 | XRE family transcriptional regulator | - |
M2J79_RS17850 (M2J79_17840) | 3819913..3820311 | - | 399 | WP_003088123.1 | NADH-quinone oxidoreductase subunit A | - |
M2J79_RS17855 (M2J79_17845) | 3820324..3820647 | - | 324 | WP_003102734.1 | multidrug efflux SMR transporter | - |
M2J79_RS17860 (M2J79_17850) | 3820978..3821439 | + | 462 | WP_003102736.1 | (2Fe-2S)-binding protein | - |
M2J79_RS17865 (M2J79_17855) | 3821444..3823639 | + | 2196 | WP_003139882.1 | xanthine dehydrogenase family protein molybdopterin-binding subunit | - |
M2J79_RS17870 (M2J79_17860) | 3823797..3824351 | + | 555 | WP_003088112.1 | helix-turn-helix transcriptional regulator | Antitoxin |
M2J79_RS17875 (M2J79_17865) | 3824439..3825017 | + | 579 | WP_003110488.1 | HD domain-containing protein | Toxin |
M2J79_RS17880 (M2J79_17870) | 3825126..3826313 | - | 1188 | WP_003139884.1 | HlyD family efflux transporter periplasmic adaptor subunit | - |
M2J79_RS17885 (M2J79_17875) | 3826303..3828474 | - | 2172 | WP_003139887.1 | type I secretion system permease/ATPase | - |
M2J79_RS17890 (M2J79_17880) | 3828464..3829741 | - | 1278 | WP_003139889.1 | TolC family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 193 a.a. Molecular weight: 21913.75 Da Isoelectric Point: 5.3655
>T244160 WP_003110488.1 NZ_CP096913:3824439-3825017 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGETAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGETAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA
Download Length: 579 bp
Antitoxin
Download Length: 185 a.a. Molecular weight: 20454.63 Da Isoelectric Point: 8.1590
>AT244160 WP_003088112.1 NZ_CP096913:3823797-3824351 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL
Download Length: 555 bp
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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