Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3823797..3825017 Replicon chromosome
Accession NZ_CP096913
Organism Pseudomonas aeruginosa strain NY7610

Toxin (Protein)


Gene name vapC Uniprot ID A0A0H2Z8V4
Locus tag M2J79_RS17875 Protein ID WP_003110488.1
Coordinates 3824439..3825017 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag M2J79_RS17870 Protein ID WP_003088112.1
Coordinates 3823797..3824351 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2J79_RS17845 (M2J79_17835) 3819365..3819916 + 552 WP_003139878.1 XRE family transcriptional regulator -
M2J79_RS17850 (M2J79_17840) 3819913..3820311 - 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
M2J79_RS17855 (M2J79_17845) 3820324..3820647 - 324 WP_003102734.1 multidrug efflux SMR transporter -
M2J79_RS17860 (M2J79_17850) 3820978..3821439 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
M2J79_RS17865 (M2J79_17855) 3821444..3823639 + 2196 WP_003139882.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
M2J79_RS17870 (M2J79_17860) 3823797..3824351 + 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
M2J79_RS17875 (M2J79_17865) 3824439..3825017 + 579 WP_003110488.1 HD domain-containing protein Toxin
M2J79_RS17880 (M2J79_17870) 3825126..3826313 - 1188 WP_003139884.1 HlyD family efflux transporter periplasmic adaptor subunit -
M2J79_RS17885 (M2J79_17875) 3826303..3828474 - 2172 WP_003139887.1 type I secretion system permease/ATPase -
M2J79_RS17890 (M2J79_17880) 3828464..3829741 - 1278 WP_003139889.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

5'-deoxynucleotidase YfbR/HDDC2

(7-188)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21913.75 Da        Isoelectric Point: 5.3655

>T244160 WP_003110488.1 NZ_CP096913:3824439-3825017 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGETAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT244160 WP_003088112.1 NZ_CP096913:3823797-3824351 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2Z8V4

Antitoxin

Source ID Structure

References