Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /Xre(antitoxin) |
| Location | 4524184..4525442 | Replicon | chromosome |
| Accession | NZ_CP096912 | ||
| Organism | Pseudomonas aeruginosa strain NY7770 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | A0A509JCW5 |
| Locus tag | M2J78_RS21040 | Protein ID | WP_021264413.1 |
| Coordinates | 4524184..4524939 (-) | Length | 252 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | V6AJU7 |
| Locus tag | M2J78_RS21045 | Protein ID | WP_003086329.1 |
| Coordinates | 4525074..4525442 (-) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| M2J78_RS21030 (M2J78_20990) | 4519355..4521898 | + | 2544 | WP_023101446.1 | acyl-homoserine-lactone acylase QuiP | - |
| M2J78_RS21035 (M2J78_20995) | 4522053..4523414 | - | 1362 | WP_073647918.1 | DNA recombination protein RmuC | - |
| M2J78_RS21040 (M2J78_21000) | 4524184..4524939 | - | 756 | WP_021264413.1 | RES family NAD+ phosphorylase | Toxin |
| M2J78_RS21045 (M2J78_21005) | 4525074..4525442 | - | 369 | WP_003086329.1 | DUF2384 domain-containing protein | Antitoxin |
| M2J78_RS21050 (M2J78_21010) | 4525515..4526801 | - | 1287 | WP_003086327.1 | FAD-binding oxidoreductase | - |
| M2J78_RS21055 (M2J78_21015) | 4526857..4528446 | - | 1590 | WP_003123191.1 | aldehyde dehydrogenase family protein | - |
| M2J78_RS21060 (M2J78_21020) | 4528525..4529001 | + | 477 | WP_019486191.1 | elongation factor GreAB | - |
| M2J78_RS21065 (M2J78_21025) | 4529004..4529279 | - | 276 | WP_023088486.1 | zinc ribbon domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 252 a.a. Molecular weight: 28217.33 Da Isoelectric Point: 8.0554
>T244155 WP_021264413.1 NZ_CP096912:c4524939-4524184 [Pseudomonas aeruginosa]
VSEIWRQCKGERHVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLQTAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAIRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA
VSEIWRQCKGERHVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLQTAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAIRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA
Download Length: 756 bp
Antitoxin
Download Length: 123 a.a. Molecular weight: 13367.63 Da Isoelectric Point: 9.9874
>AT244155 WP_003086329.1 NZ_CP096912:c4525442-4525074 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV
Download Length: 369 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A509JCW5 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | V6AJU7 |