244154

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 2844444..2845664 Replicon chromosome
Accession NZ_CP096912
Organism Pseudomonas aeruginosa strain NY7770

Toxin (Protein)


Gene name vapC Uniprot ID A0A0H2Z8V4
Locus tag M2J78_RS13320 Protein ID WP_003110488.1
Coordinates 2844444..2845022 (-) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag M2J78_RS13325 Protein ID WP_021264660.1
Coordinates 2845110..2845664 (-) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2J78_RS13305 (M2J78_13290) 2840272..2842443 + 2172 WP_003088105.1 type I secretion system permease/ATPase -
M2J78_RS13310 (M2J78_13295) 2842433..2843620 + 1188 WP_021264658.1 HlyD family efflux transporter periplasmic adaptor subunit -
M2J78_RS13315 (M2J78_13300) 2843818..2844447 + 630 WP_023101338.1 LysE family translocator -
M2J78_RS13320 (M2J78_13305) 2844444..2845022 - 579 WP_003110488.1 HD domain-containing protein Toxin
M2J78_RS13325 (M2J78_13310) 2845110..2845664 - 555 WP_021264660.1 helix-turn-helix transcriptional regulator Antitoxin
M2J78_RS13330 (M2J78_13315) 2845822..2848017 - 2196 WP_270117390.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
M2J78_RS13335 (M2J78_13320) 2848022..2848483 - 462 WP_003102736.1 (2Fe-2S)-binding protein -
M2J78_RS13340 (M2J78_13325) 2848814..2849137 + 324 WP_003102734.1 multidrug efflux SMR transporter -
M2J78_RS13345 (M2J78_13330) 2849150..2849548 + 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
M2J78_RS13350 (M2J78_13335) 2849545..2850096 - 552 WP_003132721.1 XRE family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

5'-deoxynucleotidase YfbR/HDDC2

(7-188)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21913.75 Da        Isoelectric Point: 5.3655

>T244154 WP_003110488.1 NZ_CP096912:c2845022-2844444 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGETAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20484.66 Da        Isoelectric Point: 8.1590

>AT244154 WP_021264660.1 NZ_CP096912:c2845664-2845110 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRIKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLESAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2Z8V4

Antitoxin

Source ID Structure

References