Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RHH
Location 18900..19450 Replicon plasmid pNY8688-NR
Accession NZ_CP096911
Organism Pseudomonas aeruginosa strain NY8688

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag M2J77_RS32575 Protein ID WP_019727125.1
Coordinates 19175..19450 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A6B1YL09
Locus tag M2J77_RS32570 Protein ID WP_019727126.1
Coordinates 18900..19175 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2J77_RS32530 (M2J77_32455) 14401..14778 - 378 WP_019727137.1 hypothetical protein -
M2J77_RS32535 (M2J77_32460) 14821..15105 - 285 WP_019727136.1 hypothetical protein -
M2J77_RS32540 (M2J77_32465) 15164..15415 + 252 WP_058130599.1 hypothetical protein -
M2J77_RS32545 (M2J77_32470) 15465..15713 - 249 WP_058130600.1 hypothetical protein -
M2J77_RS32550 (M2J77_32475) 16151..16603 - 453 WP_019727132.1 DNA repair protein RadC -
M2J77_RS32555 (M2J77_32480) 17253..17561 - 309 WP_019727129.1 TrfB-related DNA-binding protein -
M2J77_RS32560 (M2J77_32485) 17885..18178 - 294 WP_019727128.1 hypothetical protein -
M2J77_RS32565 (M2J77_32490) 18239..18625 - 387 WP_019727127.1 hypothetical protein -
M2J77_RS32570 (M2J77_32495) 18900..19175 + 276 WP_019727126.1 ribbon-helix-helix domain-containing protein Antitoxin
M2J77_RS32575 (M2J77_32500) 19175..19450 + 276 WP_019727125.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M2J77_RS32580 (M2J77_32505) 19541..19957 - 417 WP_196994199.1 hypothetical protein -
M2J77_RS32585 (M2J77_32510) 20439..20759 - 321 WP_196994198.1 hypothetical protein -
M2J77_RS32590 (M2J77_32515) 20855..21058 - 204 WP_031757130.1 helix-turn-helix transcriptional regulator -
M2J77_RS32595 (M2J77_32520) 21055..21294 - 240 WP_196994197.1 anti-CRISPR protein -
M2J77_RS32600 (M2J77_32525) 21307..21729 - 423 WP_196994196.1 anti-CRISPR protein AcrF3 -
M2J77_RS32605 (M2J77_32530) 21752..22054 - 303 WP_023131919.1 anti-CRISPR protein AcrE1 -
M2J77_RS32610 (M2J77_32535) 22163..22840 - 678 WP_034018017.1 SOS response-associated peptidase -
M2J77_RS32615 (M2J77_32540) 23426..23680 - 255 WP_196994195.1 hypothetical protein -
M2J77_RS32620 (M2J77_32545) 23707..23913 - 207 WP_152996423.1 hypothetical protein -
M2J77_RS32625 (M2J77_32550) 24026..24325 - 300 WP_196994194.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..58793 58793


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(11-48)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10779.36 Da        Isoelectric Point: 7.1659

>T244150 WP_019727125.1 NZ_CP096911:19175-19450 [Pseudomonas aeruginosa]
MELKWTSKGLSDVARLYEFLATVNREAAARTVQQLTSAPTALLTNPRLGERLEEFEPRDVRRILIGHYEMRYEILDSCIY
VLRLWHTREDR

Download         Length: 276 bp

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10142.32 Da        Isoelectric Point: 4.8433

>AT244150 WP_019727126.1 NZ_CP096911:18900-19175 [Pseudomonas aeruginosa]
MSTAAKPTRTVTAHVPVDLAERVDAIAERLERSKNWIVRQALSAWIDQEDERSRLTREALDDVDAGRVVDHQAVQAWAES
LGTDSPLPVPR

Download         Length: 276 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A6B1YL09

References