Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 5033129..5034637 Replicon chromosome
Accession NZ_CP096909
Organism Pseudomonas aeruginosa strain NY8688

Toxin (Protein)


Gene name - Uniprot ID Q9HYX1
Locus tag M2J77_RS23690 Protein ID WP_003119682.1
Coordinates 5034050..5034637 (-) Length 196 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A5B3ABU1
Locus tag M2J77_RS23685 Protein ID WP_003119683.1
Coordinates 5033129..5033983 (-) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2J77_RS23670 (M2J77_23615) 5028548..5028757 + 210 WP_003115568.1 cold-shock protein -
M2J77_RS23675 (M2J77_23620) 5028818..5030692 - 1875 WP_003122443.1 MFS transporter -
M2J77_RS23680 (M2J77_23625) 5030867..5033032 - 2166 WP_003122442.1 TonB-dependent receptor family protein -
M2J77_RS23685 (M2J77_23630) 5033129..5033983 - 855 WP_003119683.1 AraC family transcriptional regulator Antitoxin
M2J77_RS23690 (M2J77_23635) 5034050..5034637 - 588 WP_003119682.1 GNAT family protein Toxin
M2J77_RS23695 (M2J77_23640) 5034903..5038382 + 3480 WP_003117605.1 PAS domain-containing hybrid sensor histidine kinase/response regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(20-152)

Antitoxin

AraC-type arabinose-binding/dimerisation domain

(19-151)


Sequences

Toxin        


Download         Length: 196 a.a.        Molecular weight: 21901.23 Da        Isoelectric Point: 9.8676

>T244148 WP_003119682.1 NZ_CP096909:c5034637-5034050 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAALEASFTG

Download         Length: 588 bp

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31875.19 Da        Isoelectric Point: 7.5295

>AT244148 WP_003119683.1 NZ_CP096909:c5033983-5033129 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHAGSLETQTRWRETVLALFRRH
ARLPEAPKAGQEPLAVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTIYE

Download         Length: 855 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 1YRE
PDB 8GXJ

Antitoxin

Source ID Structure
AlphaFold DB A0A5B3ABU1

References